1r9k
From Proteopedia
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| - | {{STRUCTURE_1r9k| PDB=1r9k | SCENE= }} | ||
| - | ===Representative solution structure of the catalytic domain of SopE2=== | ||
| - | {{ABSTRACT_PUBMED_15379540}} | ||
| - | == | + | ==Representative solution structure of the catalytic domain of SopE2== |
| - | [[http://www.uniprot.org/uniprot/SOPE2_SALTY SOPE2_SALTY | + | <StructureSection load='1r9k' size='340' side='right'caption='[[1r9k]]' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[1r9k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R9K FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r9k OCA], [https://pdbe.org/1r9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r9k RCSB], [https://www.ebi.ac.uk/pdbsum/1r9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r9k ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | < | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/SOPE2_SALTY SOPE2_SALTY] Activator for CDC42 by directly engaging this Rho GTPase and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells. Also activates NF-kB, p38 and ERK kinases, which are known to be involved in the induction of IL-8 expression. Chaperone InvB is required for secretion, translocation and stabilization of intracellular levels of sopE2.<ref>PMID:10931274</ref> <ref>PMID:15321998</ref> |
| - | [[Category: | + | == Evolutionary Conservation == |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | [[Category: | + | Check<jmol> |
| - | [[Category: | + | <jmolCheckbox> |
| - | [[Category: | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/1r9k_consurf.spt"</scriptWhenChecked> |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | + | </jmolCheckbox> | |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r9k ConSurf]. | |
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]] | ||
| + | [[Category: Bagby S]] | ||
| + | [[Category: Galyov EE]] | ||
| + | [[Category: Williams C]] | ||
Current revision
Representative solution structure of the catalytic domain of SopE2
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