2voe
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="2voe" size="350" color="white" frame="true" align="right" spinBox="true" caption="2voe, resolution 2.60Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:2voe.jpg|left|200px]]<br /><applet load="2voe" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2voe, resolution 2.60Å" /> | ||
| - | '''CRYSTAL STRUCTURE OF RV2780 FROM M. TUBERCULOSIS H37RV'''<br /> | ||
| - | == | + | ==Crystal structure of Rv2780 from M. tuberculosis H37Rv== |
| - | + | <StructureSection load='2voe' size='340' side='right'caption='[[2voe]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | [[ | + | == Structural highlights == |
| - | + | <table><tr><td colspan='2'>[[2voe]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOE FirstGlance]. <br> | |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2voe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voe OCA], [https://pdbe.org/2voe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2voe RCSB], [https://www.ebi.ac.uk/pdbsum/2voe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2voe ProSAT]</span></td></tr> |
| - | [ | + | </table> |
| - | [[ | + | == Function == |
| - | [ | + | [https://www.uniprot.org/uniprot/DHA_MYCTU DHA_MYCTU] Catalyzes the reversible reductive amination of pyruvate to L-alanine. However, since the physiological environment of M.tuberculosis has a neutral pH, it can be assumed that the enzyme catalyzes exclusively the formation of L-alanine. May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.<ref>PMID:10527947</ref> |
| - | [[Category: | + | == Evolutionary Conservation == |
| - | [[Category: | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[Category: | + | Check<jmol> |
| - | [[Category: | + | <jmolCheckbox> |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2voe_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2voe ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
| + | [[Category: Ramachandran R]] | ||
| + | [[Category: Tripathi SM]] | ||
Current revision
Crystal structure of Rv2780 from M. tuberculosis H37Rv
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