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4o7q

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{{STRUCTURE_4o7q| PDB=4o7q | SCENE= }}
 
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===Crystal Structure of the F27G AIM2 Pyrin Domain Mutant and Similarities of its Self-association to DED/DED Interactions===
 
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{{ABSTRACT_PUBMED_24406744}}
 
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==Function==
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==Crystal Structure of the F27G AIM2 Pyrin Domain Mutant and Similarities of its Self-association to DED/DED Interactions==
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[[http://www.uniprot.org/uniprot/AIM2_HUMAN AIM2_HUMAN]] Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.<ref>PMID:16432157</ref> <ref>PMID:17726700</ref> <ref>PMID:19158679</ref> <ref>PMID:19158676</ref> <ref>PMID:19158675</ref> <ref>PMID:20566831</ref>
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<StructureSection load='4o7q' size='340' side='right'caption='[[4o7q]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4o7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O7Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o7q OCA], [https://pdbe.org/4o7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o7q RCSB], [https://www.ebi.ac.uk/pdbsum/4o7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o7q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AIM2_HUMAN AIM2_HUMAN] Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.<ref>PMID:16432157</ref> <ref>PMID:17726700</ref> <ref>PMID:19158679</ref> <ref>PMID:19158676</ref> <ref>PMID:19158675</ref> <ref>PMID:20566831</ref>
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==About this Structure==
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==See Also==
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[[4o7q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O7Q OCA].
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*[[Pyrin domain|Pyrin domain]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:024406744</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Human]]
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</StructureSection>
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[[Category: Kabaleeswaran, V.]]
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[[Category: Homo sapiens]]
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[[Category: Lu, A.]]
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[[Category: Large Structures]]
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[[Category: Wu, H.]]
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[[Category: Kabaleeswaran V]]
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[[Category: Apoptosis]]
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[[Category: Lu A]]
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[[Category: Inflammasome]]
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[[Category: Wu H]]
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[[Category: Pyd/dd]]
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[[Category: Signal transduction]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of the F27G AIM2 Pyrin Domain Mutant and Similarities of its Self-association to DED/DED Interactions

PDB ID 4o7q

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