3c78

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(New page: 200px<br /><applet load="3c78" size="350" color="white" frame="true" align="right" spinBox="true" caption="3c78, resolution 0.98&Aring;" /> '''0.98 A crystal struc...)
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[[Image:3c78.jpg|left|200px]]<br /><applet load="3c78" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="3c78, resolution 0.98&Aring;" />
 
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'''0.98 A crystal structure of nitrophorin 4 from Rhodnius prolixus containing FE(III) 2,4 dimethyl deuteroporphyrin ix complexed with ammonia at ph 7.5'''<br />
 
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==About this Structure==
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==0.98 A crystal structure of nitrophorin 4 from Rhodnius prolixus containing FE(III) 2,4 dimethyl deuteroporphyrin ix complexed with ammonia at ph 7.5==
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3C78 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus] with <scene name='pdbligand=NH3:'>NH3</scene> and <scene name='pdbligand=FDD:'>FDD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. This structure supersedes the now removed PDB entry 2AT7. Known structural/functional Sites: <scene name='pdbsite=AC1:Nh3+Binding+Site+For+Residue+X+700'>AC1</scene> and <scene name='pdbsite=AC2:Fdd+Binding+Site+For+Residue+X+185'>AC2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C78 OCA].
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<StructureSection load='3c78' size='340' side='right'caption='[[3c78]], [[Resolution|resolution]] 0.98&Aring;' scene=''>
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[[Category: Rhodnius prolixus]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[3c78]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2at7 2at7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C78 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C78 FirstGlance]. <br>
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[[Category: Amoia, A M.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.98&#8491;</td></tr>
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[[Category: Montfort, W R.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FDD:FE(III)+2,4-DIMETHYL+DEUTEROPORPHYRIN+IX'>FDD</scene>, <scene name='pdbligand=NH3:AMMONIA'>NH3</scene></td></tr>
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[[Category: FDD]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c78 OCA], [https://pdbe.org/3c78 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c78 RCSB], [https://www.ebi.ac.uk/pdbsum/3c78 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c78 ProSAT]</span></td></tr>
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[[Category: NH3]]
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</table>
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[[Category: beta barrel]]
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== Function ==
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[[Category: fe(iii) 2,4 dimethyl deuteroporphyrin ix]]
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[https://www.uniprot.org/uniprot/NP4_RHOPR NP4_RHOPR] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).
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[[Category: ferric]]
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== Evolutionary Conservation ==
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[[Category: heme analog]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: iron]]
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Check<jmol>
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[[Category: lipocalin]]
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<jmolCheckbox>
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[[Category: metal-binding]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/3c78_consurf.spt"</scriptWhenChecked>
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[[Category: secreted]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: transport protein]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: vasoactive]]
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</jmolCheckbox>
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[[Category: vasodilator]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c78 ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 5 13:24:37 2008''
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==See Also==
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*[[Nitrophorin|Nitrophorin]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Rhodnius prolixus]]
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[[Category: Amoia AM]]
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[[Category: Montfort WR]]

Current revision

0.98 A crystal structure of nitrophorin 4 from Rhodnius prolixus containing FE(III) 2,4 dimethyl deuteroporphyrin ix complexed with ammonia at ph 7.5

PDB ID 3c78

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