4nsd

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{{STRUCTURE_4nsd| PDB=4nsd | SCENE= }}
 
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===Crystal Structure of CBARA1 in the Ca2+ Binding Form===
 
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{{ABSTRACT_PUBMED_24514027}}
 
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==Function==
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==Crystal Structure of CBARA1 in the Ca2+ Binding Form==
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[[http://www.uniprot.org/uniprot/MICU1_HUMAN MICU1_HUMAN]] Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. Acts as a gatekeeper that senses calcium level via its EF-hand domains and sets a threshold for mitochondrial calcium uptake by MCU, thereby preventing mitochondrial calcium overload. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.<ref>PMID:16002733</ref> <ref>PMID:20693986</ref> <ref>PMID:23101630</ref> <ref>PMID:22904319</ref>
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<StructureSection load='4nsd' size='340' side='right'caption='[[4nsd]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4nsd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NSD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nsd OCA], [https://pdbe.org/4nsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nsd RCSB], [https://www.ebi.ac.uk/pdbsum/4nsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nsd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MICU1_HUMAN MICU1_HUMAN] Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. Acts as a gatekeeper that senses calcium level via its EF-hand domains and sets a threshold for mitochondrial calcium uptake by MCU, thereby preventing mitochondrial calcium overload. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.<ref>PMID:16002733</ref> <ref>PMID:20693986</ref> <ref>PMID:23101630</ref> <ref>PMID:22904319</ref>
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==About this Structure==
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==See Also==
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[[4nsd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NSD OCA].
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*[[Calcium uptake protein|Calcium uptake protein]]
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*[[Calcium uptake protein 3D structures|Calcium uptake protein 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:024514027</ref><references group="xtra"/><references/>
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<references/>
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[[Category: Human]]
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__TOC__
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[[Category: Li, S.]]
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</StructureSection>
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[[Category: Shen, Y.]]
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[[Category: Homo sapiens]]
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[[Category: Wang, L.]]
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[[Category: Large Structures]]
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[[Category: Yang, X.]]
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[[Category: Li S]]
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[[Category: Calcium binding protein]]
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[[Category: Shen Y]]
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[[Category: Ef-hand]]
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[[Category: Wang L]]
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[[Category: Yang X]]

Current revision

Crystal Structure of CBARA1 in the Ca2+ Binding Form

PDB ID 4nsd

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