3cbq

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(New page: 200px<br /><applet load="3cbq" size="350" color="white" frame="true" align="right" spinBox="true" caption="3cbq, resolution 1.820&Aring;" /> '''Crystal structure o...)
Current revision (12:25, 30 August 2023) (edit) (undo)
 
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[[Image:3cbq.jpg|left|200px]]<br /><applet load="3cbq" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="3cbq, resolution 1.820&Aring;" />
 
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'''Crystal structure of the human REM2 GTPase with bound GDP'''<br />
 
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==About this Structure==
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==Crystal structure of the human REM2 GTPase with bound GDP==
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3CBQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=GDP:'>GDP</scene>, <scene name='pdbligand=EDO:'>EDO</scene> and <scene name='pdbligand=UNX:'>UNX</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+A+301'>AC1</scene>, <scene name='pdbsite=AC2:Gdp+Binding+Site+For+Residue+A+302'>AC2</scene>, <scene name='pdbsite=AC3:Edo+Binding+Site+For+Residue+A+303'>AC3</scene>, <scene name='pdbsite=AC4:Edo+Binding+Site+For+Residue+A+304'>AC4</scene> and <scene name='pdbsite=AC5:Unx+Binding+Site+For+Residue+A+1'>AC5</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBQ OCA].
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<StructureSection load='3cbq' size='340' side='right'caption='[[3cbq]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[3cbq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CBQ FirstGlance]. <br>
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[[Category: Arrowsmith, C H.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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[[Category: Bochkarev, A.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[Category: Bountra, C.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cbq OCA], [https://pdbe.org/3cbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cbq RCSB], [https://www.ebi.ac.uk/pdbsum/3cbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cbq ProSAT]</span></td></tr>
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[[Category: Edwards, A M.]]
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</table>
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[[Category: MacKenzie, F.]]
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== Function ==
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[[Category: Nedyalkova, L.]]
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[https://www.uniprot.org/uniprot/REM2_HUMAN REM2_HUMAN] Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis (By similarity).
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[[Category: Park, H.]]
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== Evolutionary Conservation ==
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Shen, Y.]]
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Check<jmol>
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[[Category: Tempel, W.]]
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<jmolCheckbox>
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[[Category: Tong, Y.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cb/3cbq_consurf.spt"</scriptWhenChecked>
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[[Category: Weigelt, J.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: EDO]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: GDP]]
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</jmolCheckbox>
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[[Category: MG]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cbq ConSurf].
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[[Category: UNX]]
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<div style="clear:both"></div>
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[[Category: flj38964a]]
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[[Category: gdp]]
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[[Category: gtp-binding]]
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[[Category: membrane]]
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[[Category: nucleotide binding protein]]
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[[Category: nucleotide-binding]]
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[[Category: sgc]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 5 13:25:10 2008''
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==See Also==
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev A]]
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[[Category: Bountra C]]
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[[Category: Edwards AM]]
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[[Category: MacKenzie F]]
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[[Category: Nedyalkova L]]
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[[Category: Park H]]
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[[Category: Shen Y]]
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[[Category: Tempel W]]
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[[Category: Tong Y]]
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[[Category: Weigelt J]]

Current revision

Crystal structure of the human REM2 GTPase with bound GDP

PDB ID 3cbq

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