4cyy

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(New page: '''Unreleased structure''' The entry 4cyy is ON HOLD Authors: Boersma, Y.L., Newman, J., Adams, T.E., Sparrow, L., Cowieson, N., Lucent, D., Krippner, G., Bozaoglu, K., Peat, T.S. Desc...)
Current revision (12:18, 20 December 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4cyy is ON HOLD
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==The structure of vanin-1: defining the link between metabolic disease, oxidative stress and inflammation==
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<StructureSection load='4cyy' size='340' side='right'caption='[[4cyy]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4cyy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CYY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.89&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cyy OCA], [https://pdbe.org/4cyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cyy RCSB], [https://www.ebi.ac.uk/pdbsum/4cyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cyy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VNN1_HUMAN VNN1_HUMAN] Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.<ref>PMID:10567687</ref> <ref>PMID:11491533</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Although part of the coenzyme A pathway, vanin 1 (also known as pantetheinase) sits on the cell surface of many cell types as an ectoenzyme, catalyzing the breakdown of pantetheine to pantothenic acid (vitamin B5) and cysteamine, a strong reducing agent. Vanin 1 was initially discovered as a protein involved in the homing of leukocytes to the thymus. Numerous studies have shown that vanin 1 is involved in inflammation, and more recent studies have shown a key role in metabolic disease. Here, the X-ray crystal structure of human vanin 1 at 2.25 A resolution is presented, which is the first reported structure from the vanin family, as well as a crystal structure of vanin 1 bound to a specific inhibitor. These structures illuminate how vanin 1 can mediate its biological roles by way of both enzymatic activity and protein-protein interactions. Furthermore, it sheds light on how the enzymatic activity is regulated by a novel allosteric mechanism at a domain interface.
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Authors: Boersma, Y.L., Newman, J., Adams, T.E., Sparrow, L., Cowieson, N., Lucent, D., Krippner, G., Bozaoglu, K., Peat, T.S.
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The structure of vanin 1: a key enzyme linking metabolic disease and inflammation.,Boersma YL, Newman J, Adams TE, Cowieson N, Krippner G, Bozaoglu K, Peat TS Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3320-9. doi:, 10.1107/S1399004714022767. Epub 2014 Nov 28. PMID:25478849<ref>PMID:25478849</ref>
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Description: The structure of vanin-1: defining the link between metabolic disease, oxidative stress and inflammation
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4cyy" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Adams TE]]
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[[Category: Boersma YL]]
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[[Category: Bozaoglu K]]
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[[Category: Cowieson N]]
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[[Category: Krippner G]]
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[[Category: Lucent D]]
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[[Category: Newman J]]
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[[Category: Peat TS]]
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[[Category: Sparrow L]]

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The structure of vanin-1: defining the link between metabolic disease, oxidative stress and inflammation

PDB ID 4cyy

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