We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

4mrt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:28, 1 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4mrt| PDB=4mrt | SCENE= }}
 
-
===Structure of the Phosphopantetheine Transferase Sfp in Complex with Coenzyme A and a Peptidyl Carrier Protein===
 
-
{{ABSTRACT_PUBMED_24704508}}
 
-
==Function==
+
==Structure of the Phosphopantetheine Transferase Sfp in Complex with Coenzyme A and a Peptidyl Carrier Protein==
-
[[http://www.uniprot.org/uniprot/TYCC_BREPA TYCC_BREPA]] Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product. [[http://www.uniprot.org/uniprot/SFP_BACSU SFP_BACSU]] Activates the seven peptidyl carrier protein (PCP) domains of surfactin synthase SRF1/2/3 by transferring the 4'-phosphopantetheinyl moiety of coenzyme A (CoA) to a serine residue. Required for cells of B.subtilis to become producers of the lipopeptide antibiotics surfactin and plipastatin B1.<ref>PMID:8939709</ref>
+
<StructureSection load='4mrt' size='340' side='right'caption='[[4mrt]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[4mrt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168] and [https://en.wikipedia.org/wiki/Brevibacillus_parabrevis Brevibacillus parabrevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MRT FirstGlance]. <br>
-
[[4mrt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRT OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
==Reference==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mrt OCA], [https://pdbe.org/4mrt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mrt RCSB], [https://www.ebi.ac.uk/pdbsum/4mrt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mrt ProSAT]</span></td></tr>
-
<ref group="xtra">PMID:024704508</ref><references group="xtra"/><references/>
+
</table>
-
[[Category: Dikic, I.]]
+
== Function ==
-
[[Category: Doetsch, V.]]
+
[https://www.uniprot.org/uniprot/TYCC_BREPA TYCC_BREPA] Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product.
-
[[Category: Guentert, P.]]
+
__TOC__
-
[[Category: Henrich, E.]]
+
</StructureSection>
-
[[Category: Kirchner, D K.]]
+
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
-
[[Category: Koepke, J.]]
+
[[Category: Brevibacillus parabrevis]]
-
[[Category: Kraas, F I.]]
+
[[Category: Large Structures]]
-
[[Category: Loehr, F.]]
+
[[Category: Dikic I]]
-
[[Category: Marahiel, M A.]]
+
[[Category: Doetsch V]]
-
[[Category: Rahighi, S.]]
+
[[Category: Guentert P]]
-
[[Category: Tufar, P.]]
+
[[Category: Henrich E]]
-
[[Category: Pcp: aminoacyl/peptidyl carrier]]
+
[[Category: Kirchner DK]]
-
[[Category: Sfp: coenzyme a binding]]
+
[[Category: Koepke J]]
-
[[Category: Sfp: phosphopantetheine transferase]]
+
[[Category: Kraas FI]]
-
[[Category: Transport protein-transferase complex]]
+
[[Category: Loehr F]]
 +
[[Category: Marahiel MA]]
 +
[[Category: Rahighi S]]
 +
[[Category: Tufar P]]

Current revision

Structure of the Phosphopantetheine Transferase Sfp in Complex with Coenzyme A and a Peptidyl Carrier Protein

PDB ID 4mrt

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools