2ah2

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{{STRUCTURE_2ah2| PDB=2ah2 | SCENE= }}
 
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===Trypanosoma cruzi trans-sialidase in complex with 2,3-difluorosialic acid (covalent intermediate)===
 
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{{ABSTRACT_PUBMED_15130470}}
 
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==About this Structure==
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==Trypanosoma cruzi trans-sialidase in complex with 2,3-difluorosialic acid (covalent intermediate)==
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[[2ah2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s0k 1s0k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AH2 OCA].
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<StructureSection load='2ah2' size='340' side='right'caption='[[2ah2]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ah2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s0k 1s0k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AH2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FSI:5-(ACETYLAMINO)-3,5-DIDEOXY-3-FLUORO-D-ERYTHRO-ALPHA-L-MANNO-NON-2-ULOPYRANOSONIC+ACID'>FSI</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ah2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ah2 OCA], [https://pdbe.org/2ah2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ah2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ah2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ah2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q26966_TRYCR Q26966_TRYCR]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ah/2ah2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ah2 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Sialidases are a superfamily of sialic-acid-releasing enzymes that are of significant interest due to their implication as virulence factors in the pathogenesis of a number of diseases. However, extensive studies of viral and microbial sialidases have failed to provide a comprehensive picture of their mechanistic properties, in part because the structures of competent enzyme-substrate complexes and reaction intermediates have never been described. Here we report these structures for the Trypanosoma cruzi trans-sialidase (TcTS), showing that catalysis by sialidases occurs via a similar mechanism to that of other retaining glycosidases, but with some intriguing differences that may have evolved in response to the substrate structure.
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==Reference==
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Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase.,Amaya MF, Watts AG, Damager I, Wehenkel A, Nguyen T, Buschiazzo A, Paris G, Frasch AC, Withers SG, Alzari PM Structure. 2004 May;12(5):775-84. PMID:15130470<ref>PMID:15130470</ref>
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<ref group="xtra">PMID:015130470</ref><references group="xtra"/><references/>
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[[Category: Exo-alpha-sialidase]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Trypanosoma cruzi]]
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</div>
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[[Category: Alzari, P M.]]
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<div class="pdbe-citations 2ah2" style="background-color:#fffaf0;"></div>
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[[Category: Amaya, M F.]]
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[[Category: Buschiazzo, A.]]
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==See Also==
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[[Category: Damager, I.]]
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*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
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[[Category: Frasch, A C.]]
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== References ==
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[[Category: Nguyen, T.]]
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<references/>
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[[Category: Paris, G.]]
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__TOC__
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[[Category: Watts, A G.]]
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</StructureSection>
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[[Category: Wehenkel, A.]]
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[[Category: Large Structures]]
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[[Category: Withers, S G.]]
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[[Category: Covalent intermediate]]
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[[Category: Hydrolase]]
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[[Category: Sialic acid]]
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[[Category: Transglycosidase]]
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[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]
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[[Category: Alzari PM]]
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[[Category: Amaya MF]]
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[[Category: Buschiazzo A]]
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[[Category: Damager I]]
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[[Category: Frasch AC]]
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[[Category: Nguyen T]]
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[[Category: Paris G]]
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[[Category: Watts AG]]
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[[Category: Wehenkel A]]
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[[Category: Withers SG]]

Current revision

Trypanosoma cruzi trans-sialidase in complex with 2,3-difluorosialic acid (covalent intermediate)

PDB ID 2ah2

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