2e6a

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{{STRUCTURE_2e6a| PDB=2e6a | SCENE= }}
 
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===Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with orotate===
 
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==Function==
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==Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with orotate==
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[[http://www.uniprot.org/uniprot/Q4D3W2_TRYCR Q4D3W2_TRYCR]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
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<StructureSection load='2e6a' size='340' side='right'caption='[[2e6a]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2e6a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E6A FirstGlance]. <br>
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[[2e6a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6A OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e6a OCA], [https://pdbe.org/2e6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e6a RCSB], [https://www.ebi.ac.uk/pdbsum/2e6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e6a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/2e6a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e6a ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Dihydroorotate dehydrogenase|Dihydroorotate dehydrogenase]]
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*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:018808149</ref><references group="xtra"/><references/>
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[[Category: Large Structures]]
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[[Category: Dihydroorotate oxidase]]
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[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]
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[[Category: Aoki, T.]]
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[[Category: Aoki T]]
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[[Category: Harada, S.]]
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[[Category: Harada S]]
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[[Category: Inaoka, D K.]]
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[[Category: Inaoka DK]]
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[[Category: Kita, K.]]
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[[Category: Kita K]]
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[[Category: Kurisu, G.]]
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[[Category: Kurisu G]]
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[[Category: Nara, T.]]
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[[Category: Nara T]]
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[[Category: Sakamoto, K.]]
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[[Category: Sakamoto K]]
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[[Category: Shiba, T.]]
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[[Category: Shiba T]]
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[[Category: Shimizu, H.]]
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[[Category: Shimizu H]]
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[[Category: Chagas disease]]
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[[Category: Dihydroorotate dehydrogenase]]
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[[Category: Energy metabolism]]
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[[Category: Flavoprotein]]
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[[Category: Fumarate reductase]]
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[[Category: Oxidoreductase]]
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[[Category: Pyrimidine biosynthesis]]
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[[Category: Redox homeostasis]]
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Current revision

Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with orotate

PDB ID 2e6a

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