2cfh

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{{STRUCTURE_2cfh| PDB=2cfh | SCENE= }}
 
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===STRUCTURE OF THE BET3-TPC6B CORE OF TRAPP===
 
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{{ABSTRACT_PUBMED_16828797}}
 
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==Function==
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==Structure of the Bet3-TPC6B core of TRAPP==
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[[http://www.uniprot.org/uniprot/TPC6B_HUMAN TPC6B_HUMAN]] May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity).
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<StructureSection load='2cfh' size='340' side='right'caption='[[2cfh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2cfh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CFH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfh OCA], [https://pdbe.org/2cfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cfh RCSB], [https://www.ebi.ac.uk/pdbsum/2cfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TPC6B_HUMAN TPC6B_HUMAN] May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/2cfh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cfh ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The transport protein particle (TRAPP) complexes are involved in the tethering process at different trafficking steps of vesicle transport. We here present the crystal structure of a human Bet3-Tpc6B heterodimer, which represents a core sub-complex in the assembly of TRAPP. We describe a conserved patch of Tpc6 with uncharged pockets, forming a putative interaction interface for an anchoring moiety at the Golgi. The structural and functional comparison of the two paralogs Tpc6A and Tpc6B, only found in some organisms, indicates redundancy and added complexity of TRAPP architecture and function. Both iso-complexes, Bet3-Tpc6A and Bet3-Tpc6B, are able to recruit Mum2, a further TRAPP subunit, and we identify the alpha1-alpha2 loop regions as a binding site for Mum2. Our study reveals similar stability of the iso-complexes and similar expression patterns of the tpc6 variants in different mouse organs. These findings raise the possibility that the Tpc6 paralogs might contribute to the formation of two distinct TRAPP complexes that differ in function.
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==About this Structure==
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Structure of the Bet3-Tpc6B core of TRAPP: two Tpc6 paralogs form trimeric complexes with Bet3 and Mum2.,Kummel D, Muller JJ, Roske Y, Henke N, Heinemann U J Mol Biol. 2006 Aug 4;361(1):22-32. Epub 2006 Jun 21. PMID:16828797<ref>PMID:16828797</ref>
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[[2cfh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFH OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:016828797</ref><references group="xtra"/><references/>
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</div>
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<div class="pdbe-citations 2cfh" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Heinemann, U.]]
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[[Category: Large Structures]]
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[[Category: Henke, N.]]
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[[Category: Heinemann U]]
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[[Category: Kummel, D.]]
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[[Category: Henke N]]
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[[Category: Muller, J J.]]
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[[Category: Kummel D]]
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[[Category: Roske, Y.]]
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[[Category: Muller JJ]]
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[[Category: Bet3]]
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[[Category: Roske Y]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Er-golgi transport]]
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[[Category: Protein transport]]
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[[Category: Tpc6]]
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[[Category: Transport]]
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[[Category: Trapp complex]]
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[[Category: Vesicle tethering]]
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Current revision

Structure of the Bet3-TPC6B core of TRAPP

PDB ID 2cfh

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