2gid

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{{STRUCTURE_2gid| PDB=2gid | SCENE= }}
 
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===Crystal structures of trypanosoma bruciei MRP1/MRP2===
 
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{{ABSTRACT_PUBMED_16923390}}
 
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==About this Structure==
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==Crystal structures of trypanosoma bruciei MRP1/MRP2==
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[[2gid]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_treu927 Trypanosoma brucei treu927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GID OCA].
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<StructureSection load='2gid' size='340' side='right'caption='[[2gid]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2gid]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei_TREU927 Trypanosoma brucei brucei TREU927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GID FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gid OCA], [https://pdbe.org/2gid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gid RCSB], [https://www.ebi.ac.uk/pdbsum/2gid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gid ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q952G2_9TRYP Q952G2_9TRYP]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The mitochondrial RNA binding proteins MRP1 and MRP2 form a heteromeric complex that functions in kinetoplastid RNA editing. In this process, MRP1/MRP2 serves as a matchmaker by binding to guide RNAs and facilitating their hybridization with cognate preedited mRNAs. To understand the mechanism by which this complex performs RNA matchmaking, we determined structures of Trypanosoma brucei apoMRP1/MRP2 and an MRP1/MRP2-gRNA complex. The structures show that MRP1/MRP2 is a heterotetramer and, despite little sequence homology, each MRP subunit exhibits the same "Whirly" transcription-factor fold. The gRNA molecule binds to the highly basic beta sheet surface of the MRP complex via nonspecific, electrostatic contacts. Strikingly, while the gRNA stem/loop II base is anchored to the basic surface, stem/loop I (the anchor sequence) is unfolded and its bases exposed to solvent. Thus, MRP1/MRP2 acts as an RNA matchmaker by stabilizing the RNA molecule in an unfolded conformation suitable for RNA-RNA hybridization.
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==Reference==
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Crystal structures of T. brucei MRP1/MRP2 guide-RNA binding complex reveal RNA matchmaking mechanism.,Schumacher MA, Karamooz E, Zikova A, Trantirek L, Lukes J Cell. 2006 Aug 25;126(4):701-11. PMID:16923390<ref>PMID:16923390</ref>
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<ref group="xtra">PMID:016923390</ref><references group="xtra"/><references/>
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[[Category: Trypanosoma brucei treu927]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Karamooz, E.]]
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</div>
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[[Category: Lukes, J.]]
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<div class="pdbe-citations 2gid" style="background-color:#fffaf0;"></div>
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[[Category: Schumacher, M A.]]
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== References ==
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[[Category: Trantirek, L.]]
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<references/>
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[[Category: Zikova, A.]]
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__TOC__
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[[Category: Guide rna]]
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</StructureSection>
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[[Category: Matchmaking]]
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[[Category: Large Structures]]
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[[Category: Rna editing]]
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[[Category: Trypanosoma brucei brucei TREU927]]
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[[Category: T. brucei]]
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[[Category: Karamooz E]]
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[[Category: Translation]]
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[[Category: Lukes J]]
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[[Category: Schumacher MA]]
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[[Category: Trantirek L]]
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[[Category: Zikova A]]

Current revision

Crystal structures of trypanosoma bruciei MRP1/MRP2

PDB ID 2gid

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