2hsg

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{{STRUCTURE_2hsg| PDB=2hsg | SCENE= }}
 
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===Structure of transcription regulator CcpA in its DNA-free state===
 
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{{ABSTRACT_PUBMED_17500051}}
 
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==Function==
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==Structure of transcription regulator CcpA in its DNA-free state==
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[[http://www.uniprot.org/uniprot/CCPA_BACME CCPA_BACME]] Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions (By similarity).
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<StructureSection load='2hsg' size='340' side='right'caption='[[2hsg]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2hsg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium Priestia megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HSG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hsg OCA], [https://pdbe.org/2hsg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hsg RCSB], [https://www.ebi.ac.uk/pdbsum/2hsg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hsg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CCPA_PRIMG CCPA_PRIMG] Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/2hsg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hsg ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The catabolite control protein A (CcpA) from Bacillus megaterium is a member of the bacterial repressor protein family GalR-LacI. CcpA functions as master transcriptional regulator of carbon catabolite repression/regulation in firmicutes. Here we present the crystal structure of full-length apo CcpA at 2.5 A resolution from B. megaterium. The structure reveals the location of the helix-turn-helix domain as well as the hinge region, which were not visible due to their high flexibility in earlier crystallographic studies on CcpA molecules. The structure of the apo CcpA homodimer in the present form is in contrast to other reported structures for CcpA.
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==About this Structure==
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Structure of full-length transcription regulator CcpA in the apo form.,Loll B, Saenger W, Biesiadka J Biochim Biophys Acta. 2007 Jun;1774(6):732-6. Epub 2007 Apr 18. PMID:17500051<ref>PMID:17500051</ref>
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[[2hsg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HSG OCA].
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==See Also==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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*[[Catabolite control protein|Catabolite control protein]]
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</div>
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<div class="pdbe-citations 2hsg" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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<ref group="xtra">PMID:017500051</ref><references group="xtra"/><references/>
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*[[Catabolite control protein 3D structures|Catabolite control protein 3D structures]]
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[[Category: Bacillus megaterium]]
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== References ==
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[[Category: Alings, C.]]
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<references/>
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[[Category: Biesiadka, J.]]
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__TOC__
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[[Category: Loll, B.]]
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</StructureSection>
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[[Category: Saenger, W.]]
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[[Category: Large Structures]]
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[[Category: Ccpa]]
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[[Category: Priestia megaterium]]
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[[Category: Transcription regulator]]
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[[Category: Alings C]]
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[[Category: Transcriptional regulator]]
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[[Category: Biesiadka J]]
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[[Category: Loll B]]
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[[Category: Saenger W]]

Current revision

Structure of transcription regulator CcpA in its DNA-free state

PDB ID 2hsg

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