1z2q

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{{STRUCTURE_1z2q| PDB=1z2q | SCENE= }}
 
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===High-resolution solution structure of the LM5-1 FYVE domain from Leishmania major===
 
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{{ABSTRACT_PUBMED_17905827}}
 
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==About this Structure==
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==High-resolution solution structure of the LM5-1 FYVE domain from Leishmania major==
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[[1z2q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z2Q OCA].
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<StructureSection load='1z2q' size='340' side='right'caption='[[1z2q]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1z2q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z2Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z2q OCA], [https://pdbe.org/1z2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z2q RCSB], [https://www.ebi.ac.uk/pdbsum/1z2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z2q ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z2/1z2q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z2q ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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FYVE domain proteins play key roles in regulating membrane traffic in eukaryotic cells. The FYVE domain displays a remarkable specificity for the head group of the target lipid, phosphatidylinositol 3-phosphate (PtdIns[3]P). We have identified five putative FYVE domain proteins in the genome of the protozoan parasite Leishmania major, three of which are predicted to contain a functional PtdIns(3)P-binding site. The FYVE domain of one of these proteins, LmFYVE-1, bound PtdIns(3)P in liposome-binding assays and targeted GFP to acidified late endosomes/lysosomes in mammalian cells. The high-resolution solution structure of its N-terminal FYVE domain (LmFYVE-1[1-79]) was solved by nuclear magnetic resonance. Functionally significant clusters of residues of the LmFYVE-1 domain involved in PtdIns(3)P binding and dependence on low pH for tight binding were identified. This structure is the first trypanosomatid membrane trafficking protein to be determined and has been refined to high precision and accuracy using residual dipolar couplings.
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==Reference==
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A high-resolution solution structure of a trypanosomatid FYVE domain.,Mertens HD, Callaghan JM, Swarbrick JD, McConville MJ, Gooley PR Protein Sci. 2007 Nov;16(11):2552-9. Epub 2007 Sep 28. PMID:17905827<ref>PMID:17905827</ref>
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<ref group="xtra">PMID:017905827</ref><references group="xtra"/><references/>
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[[Category: Leima]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Callaghan, J M.]]
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</div>
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[[Category: Gooley, P R.]]
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<div class="pdbe-citations 1z2q" style="background-color:#fffaf0;"></div>
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[[Category: McConville, M J.]]
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== References ==
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[[Category: Mertens, H D.T.]]
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<references/>
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[[Category: Fyve domain]]
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__TOC__
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[[Category: Membrane protein]]
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</StructureSection>
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[[Category: Zinc-finger]]
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[[Category: Large Structures]]
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[[Category: Leishmania major]]
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[[Category: Callaghan JM]]
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[[Category: Gooley PR]]
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[[Category: McConville MJ]]
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[[Category: Mertens HDT]]

Current revision

High-resolution solution structure of the LM5-1 FYVE domain from Leishmania major

PDB ID 1z2q

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