1xy1

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{{STRUCTURE_1xy1| PDB=1xy1 | SCENE= }}
 
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===CRYSTAL STRUCTURE ANALYSIS OF DEAMINO-OXYTOCIN. CONFORMATIONAL FLEXIBILITY AND RECEPTOR BINDING===
 
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{{ABSTRACT_PUBMED_3008332}}
 
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==About this Structure==
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==CRYSTAL STRUCTURE ANALYSIS OF DEAMINO-OXYTOCIN. CONFORMATIONAL FLEXIBILITY AND RECEPTOR BINDING==
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[[1xy1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XY1 OCA].
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<StructureSection load='1xy1' size='340' side='right'caption='[[1xy1]], [[Resolution|resolution]] 1.04&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1xy1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XY1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.04&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPT:BETA-MERCAPTOPROPIONIC+ACID'>MPT</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xy1 OCA], [https://pdbe.org/1xy1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xy1 RCSB], [https://www.ebi.ac.uk/pdbsum/1xy1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xy1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NEU1_BOVIN NEU1_BOVIN] Neurophysin 1 specifically binds oxytocin. Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Two crystal structures of deamino-oxytocin have been determined at better than 1.1A resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation.
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==Reference==
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Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding.,Wood SP, Tickle IJ, Treharne AM, Pitts JE, Mascarenhas Y, Li JY, Husain J, Cooper S, Blundell TL, Hruby VJ, et al. Science. 1986 May 2;232(4750):633-6. PMID:3008332<ref>PMID:3008332</ref>
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<ref group="xtra">PMID:003008332</ref><references group="xtra"/><references/>
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[[Category: Blundell, T L.]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Cooper, S.]]
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</div>
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[[Category: Husain, J.]]
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<div class="pdbe-citations 1xy1" style="background-color:#fffaf0;"></div>
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[[Category: Pitts, J E.]]
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== References ==
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[[Category: Tickle, I J.]]
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<references/>
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[[Category: Wood, S P.]]
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__TOC__
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[[Category: Hormone]]
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Blundell TL]]
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[[Category: Cooper S]]
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[[Category: Husain J]]
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[[Category: Pitts JE]]
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[[Category: Tickle IJ]]
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[[Category: Wood SP]]

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CRYSTAL STRUCTURE ANALYSIS OF DEAMINO-OXYTOCIN. CONFORMATIONAL FLEXIBILITY AND RECEPTOR BINDING

PDB ID 1xy1

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