2ci9
From Proteopedia
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| - | {{STRUCTURE_2ci9| PDB=2ci9 | SCENE= }} | ||
| - | ===NCK1 SH2-DOMAIN IN COMPLEX WITH A DODECAPHOSPHOPEPTIDE FROM EPEC PROTEIN TIR=== | ||
| - | {{ABSTRACT_PUBMED_16636066}} | ||
| - | == | + | ==Nck1 SH2-domain in complex with a dodecaphosphopeptide from EPEC protein Tir== |
| - | [[http://www.uniprot.org/uniprot/NCK1_HUMAN NCK1_HUMAN | + | <StructureSection load='2ci9' size='340' side='right'caption='[[2ci9]], [[Resolution|resolution]] 1.50Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[2ci9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CI9 FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ci9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ci9 OCA], [https://pdbe.org/2ci9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ci9 RCSB], [https://www.ebi.ac.uk/pdbsum/2ci9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ci9 ProSAT]</span></td></tr> | |
| - | < | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NCK1_HUMAN NCK1_HUMAN] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref> <ref>PMID:17803907</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/2ci9_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ci9 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Findeis | + | [[Category: Large Structures]] |
| - | [[Category: Frese | + | [[Category: Findeis AC]] |
| - | [[Category: Heinz | + | [[Category: Frese S]] |
| - | [[Category: Marquardt | + | [[Category: Heinz DW]] |
| - | [[Category: Roske | + | [[Category: Marquardt T]] |
| - | [[Category: Schubert | + | [[Category: Roske YS]] |
| - | [[Category: Stradal | + | [[Category: Schubert W-D]] |
| - | + | [[Category: Stradal TEB]] | |
| - | + | ||
Current revision
Nck1 SH2-domain in complex with a dodecaphosphopeptide from EPEC protein Tir
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