Ribosomal protein S15

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{{STRUCTURE_1a32| PDB=1a32 | SIZE=400| SCENE= |right|CAPTION=Ribosomal protein S15 from [[1a32]]}}
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<StructureSection load='1a32' size='350' side='right' scene='' caption='Ribosomal protein S15 (PDB code [[1a32]])'>
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'''Ribosomal protein S15''' (RPS15) is one of the 21 proteins which belong to the 30S <scene name='Ribosomal_protein_S15/Cv/2'>small subunit</scene> of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]] or the 30 proteins which belong to the 40S small subunit of the eukaryotic ribosome. It is involved in the early steps of ribosome assembly<ref>PMID:12126618</ref>.
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'''Ribosomal protein S15''' (RPS15) is one of the 22 proteins which belong to the <scene name='Ribosomal_protein_S15/Cv/2'>small subunit</scene> of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]]. It is involved in the early steps of ribosome assembly. The images at the left and at the right correspond to one representative RPS15, ''i.e.'' the crystal structure of Ribosomal protein S15 from ''Thermus thermophilus'' ([[2zm6]], chain O).
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{{TOC limit|limit=2}}
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== Relevance ==
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RPS15 phosphorylation mediates leucine-rich kinase 2 neurodegeneration in Parkinson's disease<ref>PMID:24725412</ref>.
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</StructureSection>
== 3D Structures of Ribosomal protein S15 ==
== 3D Structures of Ribosomal protein S15 ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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=== S15 ===
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*Ribosomal protein S15
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[[1a32]] – RPS15 – ''Geobacillus stearothermophilus''<br />
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**[[1a32]] – RPS15 – ''Geobacillus stearothermophilus''<br />
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[[1ab3]], [[2fkx]] - TtRPS15 – ''Thermus thermophilus'' - NMR<br />
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**[[1ab3]], [[2fkx]] - TtRPS15 – ''Thermus thermophilus'' - NMR<br />
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[[1kuq]], [[1f7y]], [[1dk1]] - TtRPS15+16S RRNA fragment<br />
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**[[1kuq]], [[1f7y]], [[1dk1]] - TtRPS15+16S RRNA fragment<br />
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[[2vaz]] – EcRPS15+RPSO mRNA operator – ''Escherichia coli'' – Cryo-EM<br />
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**[[2vaz]] – EcRPS15+RPSO mRNA operator – ''Escherichia coli'' – Cryo-EM<br />
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[[3ulw]], [[4iyl]] – RPS15 – ''Campylobacter jejuni''<br />
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**[[4iyl]] – RPS15 – ''Campylobacter jejuni''<br />
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[[4a5u]] – EcRPS15 + RNA replicase polyprotein
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**[[4a5u]] – EcRPS15 + RNA replicase polyprotein
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=== S15 in part of small ribosomal subunit ===
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*Ribosomal protein S15 in part of small ribosomal subunit
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[[3iy8]] - EcRPS15+EcRPS5+EcRPS6+EcRPS9+EcRPS9 EcRPS8+EcRPS11+EcRPS12+EcRPS16+EcRPS17+EcRPS18+Leishmania taretolae mRNA<br />
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**[[3iy8]] - EcRPS15+EcRPS5+EcRPS6+EcRPS9+ EcRPS8+EcRPS11+EcRPS12+EcRPS16+EcRPS17+EcRPS18+Leishmania taretolae mRNA<br />
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[[1g1x]] - TtRPS15+TtRPS6+TtRPS18+16S RRNA fragment<br />
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**[[1g1x]] - TtRPS15+TtRPS6+TtRPS18+16S RRNA fragment<br />
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[[1qd7]] – TtRPS15+TtRPS4+TtRPS5+TtRPS7+TtRPS8+TtRPS6+TtRPS17+TtRPS20+16S RRNA fragment<br />
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**[[1qd7]] – TtRPS15+TtRPS4+TtRPS5+TtRPS7+TtRPS8+TtRPS6+TtRPS17+TtRPS20+16S RRNA fragment<br />
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Ribosomal protein S15 (PDB code 1a32)

Drag the structure with the mouse to rotate

3D Structures of Ribosomal protein S15

Updated on 10-October-2017

References

  1. ↑ Serganov A, Ennifar E, Portier C, Ehresmann B, Ehresmann C. Do mRNA and rRNA binding sites of E.coli ribosomal protein S15 share common structural determinants? J Mol Biol. 2002 Jul 26;320(5):963-78. PMID:12126618 doi:http://dx.doi.org/10.1016/S0022283602005533
  2. ↑ Martin I, Kim JW, Lee BD, Kang HC, Xu JC, Jia H, Stankowski J, Kim MS, Zhong J, Kumar M, Andrabi SA, Xiong Y, Dickson DW, Wszolek ZK, Pandey A, Dawson TM, Dawson VL. Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease. Cell. 2014 Apr 10;157(2):472-85. doi: 10.1016/j.cell.2014.01.064. PMID:24725412 doi:http://dx.doi.org/10.1016/j.cell.2014.01.064

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