Ribosomal protein S19

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{{STRUCTURE_2v7f| PDB=2v7f | SIZE=400| SCENE= |right|CAPTION=Ribosomal protein S19 complex with Cl- ion [[2v7f]] }}
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<StructureSection load='2v7f' size='350' side='right' scene='' caption='Ribosomal protein S19 complex with Cl- ion (PDB code [[2v7f]])'>
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== Function ==
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[[Ribosomal protein S19]] (RPS19) is one of the 22 proteins which belong to the <scene name='Ribosomal_protein_S19/Cv/2'>small subunit</scene> of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]]. It forms a complex with RPS13 that binds to 16S RRNA. The images at the left and at the right correspond to one representative RPS19, ''i.e.'' the crystal structure of Ribosomal protein S19 from ''Thermus thermophilus'' ([[2zm6]], chain S).
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[[Ribosomal protein S19]] (RPS19) is one of the 21 proteins which belong to the 30S <scene name='Ribosomal_protein_S19/Cv/2'>small subunit</scene> of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]] or the 30 proteins which belong to the 40S small subunit of the eukaryotic ribosome. It forms a complex with RPS13 that binds to 16S RRNA<ref>PMID:8722009</ref>.
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== Relevance ==
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RPS19 is a potent anti-inflammatory agent which appears to work primarily by inhibiting MIF signaling<ref>PMID:23252627</ref>.
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</StructureSection>
== 3D Structures of Ribosomal protein S19 ==
== 3D Structures of Ribosomal protein S19 ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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===S19===
 
[[2v7f]] – RPS19 – ''Pyroccocus abyssi''<br />
[[2v7f]] – RPS19 – ''Pyroccocus abyssi''<br />
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[[1qkh]], [[1qkf]] - TtRPS19 - ''Thermus thermophilus'' – NMR
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[[1qkh]], [[1qkf]] - TtRPS19 - ''Thermus thermophilus'' – NMR<br />
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[[3a1p]] – TtRPS19 + ribosome maturation factor<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Ribosomal protein S19 complex with Cl- ion (PDB code 2v7f)

Drag the structure with the mouse to rotate

3D Structures of Ribosomal protein S19

Updated on 01-October-2017

2v7f – RPS19 – Pyroccocus abyssi
1qkh, 1qkf - TtRPS19 - Thermus thermophilus – NMR
3a1p – TtRPS19 + ribosome maturation factor

References

  1. ↑ Wool IG, Chan YL, Gluck A. Structure and evolution of mammalian ribosomal proteins. Biochem Cell Biol. 1995 Nov-Dec;73(11-12):933-47. PMID:8722009
  2. ↑ Lv J, Huang XR, Klug J, Frohlich S, Lacher P, Xu A, Meinhardt A, Lan HY. Ribosomal protein S19 is a novel therapeutic agent in inflammatory kidney disease. Clin Sci (Lond). 2013 May;124(10):627-37. doi: 10.1042/CS20120526. PMID:23252627 doi:http://dx.doi.org/10.1042/CS20120526

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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