4pdj
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Neutron crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+== | |
| + | <StructureSection load='4pdj' size='340' side='right'caption='[[4pdj]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4pdj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PDJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PDJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Hybrid , Neutron Diffraction , X-ray diffraction, [[Resolution|Resolution]] 1.599Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DHF:DIHYDROFOLIC+ACID'>DHF</scene>, <scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pdj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pdj OCA], [https://pdbe.org/4pdj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pdj RCSB], [https://www.ebi.ac.uk/pdbsum/4pdj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pdj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | ||
| - | + | ==See Also== | |
| - | + | *[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli K-12]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bennett B]] | ||
| + | [[Category: Dealwis C]] | ||
| + | [[Category: Kovalevsky AY]] | ||
| + | [[Category: Langan P]] | ||
| + | [[Category: Wan Q]] | ||
| + | [[Category: Wilson M]] | ||
Current revision
Neutron crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+
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