4pqg

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'''Unreleased structure'''
 
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The entry 4pqg is ON HOLD until Paper Publication
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==Crystal structure of the pneumococcal O-GlcNAc transferase GtfA in complex with UDP and GlcNAc==
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<StructureSection load='4pqg' size='340' side='right'caption='[[4pqg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4pqg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PQG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqg OCA], [https://pdbe.org/4pqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pqg RCSB], [https://www.ebi.ac.uk/pdbsum/4pqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pqg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GTFA_STRPN GTFA_STRPN] Required for the polymorphic O-glycosylation of serine-rich repeat protein PsrP. Catalyzes the first step in glycosylation by transferring N-acetylglucosamine from UDP-GlcNAc to serine residues in PsrP (PubMed:24936067, PubMed:28246170). Part of the accessory SecA2/SecY2 system specifically required to export serine-rich repeat cell wall proteins encoded upstream in the same operon (Probable). The GtfA-GtfB complex adds GlcNAc from UDP-GlcNAc to PsrP (experimentally characterized with truncated PsrP-SSR1 constructs); this subunit alone has weak N-acetylglucosaminyl transferase activity that is 10-fold stimulated by GtfB. The complex requires at least a 25 residue-long peptide for activity; the in vitro assay has only been seen to glycosylate Ser residues (PubMed:24936067). The alpha linkage was shown in L.reuteri.[UniProtKB:A0A0S4NM89]<ref>PMID:24936067</ref> <ref>PMID:28246170</ref> <ref>PMID:16861665</ref>
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Authors: Shi, W.W., Jiang, Y.L., Zhu, F., Yang, Y.H., Wu, H., Ren, Y.M., Chen, Y., Zhou, C.Z.
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==See Also==
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*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
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Description: Crystal structure of the pneumococcal O-GlcNAc transferase GtfA in complex with UDP and GlcNAc
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*[[O-GlcNAc transferase 3D structures|O-GlcNAc transferase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Streptococcus pneumoniae TIGR4]]
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[[Category: Chen Y]]
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[[Category: Jiang YL]]
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[[Category: Ren YM]]
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[[Category: Shi WW]]
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[[Category: Wu H]]
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[[Category: Yang YH]]
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[[Category: Zhou CZ]]
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[[Category: Zhu F]]

Current revision

Crystal structure of the pneumococcal O-GlcNAc transferase GtfA in complex with UDP and GlcNAc

PDB ID 4pqg

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