4q7g
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4q7g is ON HOLD Authors: Minasov, G., Nocadello, S., Shuvalova, L., Shatsman, S., Kwon, K., Bagnoli, F., Falugi, F., Bottomley, M., Grandi, G., Ande...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==1.7 Angstrom Crystal Structure of leukotoxin LukD from Staphylococcus aureus.== | |
| + | <StructureSection load='4q7g' size='340' side='right'caption='[[4q7g]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4q7g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MSSA476 Staphylococcus aureus subsp. aureus MSSA476]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q7G FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q7g OCA], [https://pdbe.org/4q7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q7g RCSB], [https://www.ebi.ac.uk/pdbsum/4q7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q7g ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A0H2WX25_STAAC A0A0H2WX25_STAAC] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Staphylococcal leukotoxins are a family of beta-barrel, bicomponent, pore-forming toxins with membrane-damaging functions. These bacterial exotoxins share sequence and structural homology and target several host-cell types. Leukotoxin ED (LukED) is one of these bicomponent pore-forming toxins that Staphylococcus aureus produces in order to suppress the ability of the host to contain the infection. The recent delineation of the important role that LukED plays in S. aureus pathogenesis and the identification of its protein receptors, combined with its presence in S. aureus methicillin-resistant epidemic strains, establish this leukocidin as a possible target for the development of novel therapeutics. Here, the crystal structures of the water-soluble LukE and LukD components of LukED have been determined. The two structures illustrate the tertiary-structural variability with respect to the other leukotoxins while retaining the conservation of the residues involved in the interaction of the protomers in the bipartite leukotoxin in the pore complex. | ||
| - | + | Crystal structures of the components of the Staphylococcus aureus leukotoxin ED.,Nocadello S, Minasov G, Shuvalova L, Dubrovska I, Sabini E, Bagnoli F, Grandi G, Anderson WF Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):113-20. doi:, 10.1107/S2059798315023207. Epub 2016 Jan 1. PMID:26894539<ref>PMID:26894539</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 4q7g" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Staphylococcus aureus subsp. aureus MSSA476]] | ||
| + | [[Category: Anderson WF]] | ||
| + | [[Category: Bagnoli F]] | ||
| + | [[Category: Bottomley M]] | ||
| + | [[Category: Falugi F]] | ||
| + | [[Category: Grandi G]] | ||
| + | [[Category: Kwon K]] | ||
| + | [[Category: Minasov G]] | ||
| + | [[Category: Nocadello S]] | ||
| + | [[Category: Shatsman S]] | ||
| + | [[Category: Shuvalova L]] | ||
Current revision
1.7 Angstrom Crystal Structure of leukotoxin LukD from Staphylococcus aureus.
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