4p79
From Proteopedia
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==Crystal structure of mouse claudin-15== | ==Crystal structure of mouse claudin-15== | ||
| - | <StructureSection load='4p79' size='340' side='right' caption='[[4p79]], [[Resolution|resolution]] 2.40Å' scene=''> | + | <StructureSection load='4p79' size='340' side='right'caption='[[4p79]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | [[4p79]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P79 OCA]. <br> | + | <table><tr><td colspan='2'>[[4p79]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P79 FirstGlance]. <br> |
| - | <b> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p79 OCA], [https://pdbe.org/4p79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p79 RCSB], [https://www.ebi.ac.uk/pdbsum/4p79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p79 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CLD15_MOUSE CLD15_MOUSE] Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity (By similarity). | ||
| + | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Tight junctions are cell-cell adhesion structures in epithelial cell sheets that surround organ compartments in multicellular organisms and regulate the permeation of ions through the intercellular space. Claudins are the major constituents of tight junctions and form strands that mediate cell adhesion and function as paracellular barriers. We report the structure of mammalian claudin-15 at a resolution of 2.4 angstroms. The structure reveals a characteristic beta-sheet fold comprising two extracellular segments, which is anchored to a transmembrane four-helix bundle by a consensus motif. Our analyses suggest potential paracellular pathways with distinctive charges on the extracellular surface, providing insight into the molecular basis of ion homeostasis across tight junctions. | Tight junctions are cell-cell adhesion structures in epithelial cell sheets that surround organ compartments in multicellular organisms and regulate the permeation of ions through the intercellular space. Claudins are the major constituents of tight junctions and form strands that mediate cell adhesion and function as paracellular barriers. We report the structure of mammalian claudin-15 at a resolution of 2.4 angstroms. The structure reveals a characteristic beta-sheet fold comprising two extracellular segments, which is anchored to a transmembrane four-helix bundle by a consensus motif. Our analyses suggest potential paracellular pathways with distinctive charges on the extracellular surface, providing insight into the molecular basis of ion homeostasis across tight junctions. | ||
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Crystal structure of a claudin provides insight into the architecture of tight junctions.,Suzuki H, Nishizawa T, Tani K, Yamazaki Y, Tamura A, Ishitani R, Dohmae N, Tsukita S, Nureki O, Fujiyoshi Y Science. 2014 Apr 18;344(6181):304-7. doi: 10.1126/science.1248571. PMID:24744376<ref>PMID:24744376</ref> | Crystal structure of a claudin provides insight into the architecture of tight junctions.,Suzuki H, Nishizawa T, Tani K, Yamazaki Y, Tamura A, Ishitani R, Dohmae N, Tsukita S, Nureki O, Fujiyoshi Y Science. 2014 Apr 18;344(6181):304-7. doi: 10.1126/science.1248571. PMID:24744376<ref>PMID:24744376</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| + | </div> | ||
| + | <div class="pdbe-citations 4p79" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Dohmae | + | [[Category: Large Structures]] |
| - | [[Category: Fujiyoshi | + | [[Category: Mus musculus]] |
| - | [[Category: Ishitani | + | [[Category: Dohmae N]] |
| - | [[Category: Nishizawa | + | [[Category: Fujiyoshi Y]] |
| - | [[Category: Nureki | + | [[Category: Ishitani R]] |
| - | [[Category: Suzuki | + | [[Category: Nishizawa T]] |
| - | [[Category: Tamura | + | [[Category: Nureki O]] |
| - | [[Category: Tani | + | [[Category: Suzuki H]] |
| - | [[Category: Tsukita | + | [[Category: Tamura A]] |
| - | [[Category: Yamazaki | + | [[Category: Tani K]] |
| - | + | [[Category: Tsukita S]] | |
| - | + | [[Category: Yamazaki Y]] | |
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| - | + | ||
Current revision
Crystal structure of mouse claudin-15
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Categories: Large Structures | Mus musculus | Dohmae N | Fujiyoshi Y | Ishitani R | Nishizawa T | Nureki O | Suzuki H | Tamura A | Tani K | Tsukita S | Yamazaki Y
