4cni
From Proteopedia
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==Crystal structure of the Fab portion of Olokizumab in complex with IL- 6== | ==Crystal structure of the Fab portion of Olokizumab in complex with IL- 6== | ||
| - | <StructureSection load='4cni' size='340' side='right' caption='[[4cni]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='4cni' size='340' side='right'caption='[[4cni]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | [[4cni]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CNI OCA]. <br> | + | <table><tr><td colspan='2'>[[4cni]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CNI FirstGlance]. <br> |
| - | <b> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cni OCA], [https://pdbe.org/4cni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cni RCSB], [https://www.ebi.ac.uk/pdbsum/4cni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cni ProSAT]</span></td></tr> | ||
| + | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN] Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. |
| + | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Interleukin-6 (IL-6) is a critical regulator of the immune system and has been widely implicated in autoimmune disease. Here, we describe the discovery and characterization of olokizumab, a humanized antibody to IL-6. Data from structural biology, cell biology and primate pharmacology demonstrate the therapeutic potential of targeting IL-6 at "Site 3", blocking the interaction with the signaling co-receptor gp130. | Interleukin-6 (IL-6) is a critical regulator of the immune system and has been widely implicated in autoimmune disease. Here, we describe the discovery and characterization of olokizumab, a humanized antibody to IL-6. Data from structural biology, cell biology and primate pharmacology demonstrate the therapeutic potential of targeting IL-6 at "Site 3", blocking the interaction with the signaling co-receptor gp130. | ||
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Discovery and characterization of olokizumab: A humanized antibody targeting interleukin-6 and neutralizing gp130-signaling.,Shaw S, Bourne T, Meier C, Carrington B, Gelinas R, Henry A, Popplewell A, Adams R, Baker T, Rapecki S, Marshall D, Moore A, Neale H, Lawson A MAbs. 2014 May 1;6(3):773-81. doi: 10.4161/mabs.28612. Epub 2014 Apr 2. PMID:24670876<ref>PMID:24670876</ref> | Discovery and characterization of olokizumab: A humanized antibody targeting interleukin-6 and neutralizing gp130-signaling.,Shaw S, Bourne T, Meier C, Carrington B, Gelinas R, Henry A, Popplewell A, Adams R, Baker T, Rapecki S, Marshall D, Moore A, Neale H, Lawson A MAbs. 2014 May 1;6(3):773-81. doi: 10.4161/mabs.28612. Epub 2014 Apr 2. PMID:24670876<ref>PMID:24670876</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| + | </div> | ||
| + | <div class="pdbe-citations 4cni" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Interleukin 3D structures|Interleukin 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Adams | + | [[Category: Homo sapiens]] |
| - | [[Category: Baker | + | [[Category: Large Structures]] |
| - | [[Category: Bourne | + | [[Category: Adams R]] |
| - | [[Category: Carrington | + | [[Category: Baker T]] |
| - | [[Category: Gelinas | + | [[Category: Bourne T]] |
| - | [[Category: Henry | + | [[Category: Carrington B]] |
| - | [[Category: Lawson | + | [[Category: Gelinas R]] |
| - | [[Category: Marshall | + | [[Category: Henry A]] |
| - | [[Category: Meier | + | [[Category: Lawson A]] |
| - | [[Category: Neale | + | [[Category: Marshall D]] |
| - | [[Category: Popplewell | + | [[Category: Meier C]] |
| - | [[Category: Rapecki | + | [[Category: Neale H]] |
| - | [[Category: Shaw | + | [[Category: Popplewell A]] |
| - | + | [[Category: Rapecki S]] | |
| - | + | [[Category: Shaw S]] | |
| - | + | ||
Current revision
Crystal structure of the Fab portion of Olokizumab in complex with IL- 6
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Categories: Homo sapiens | Large Structures | Adams R | Baker T | Bourne T | Carrington B | Gelinas R | Henry A | Lawson A | Marshall D | Meier C | Neale H | Popplewell A | Rapecki S | Shaw S
