2lcm
From Proteopedia
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==NMR structure of S3-4 peptide== | ==NMR structure of S3-4 peptide== | ||
| - | <StructureSection load='2lcm' size='340' side='right' caption='[[2lcm | + | <StructureSection load='2lcm' size='340' side='right'caption='[[2lcm]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | [[2lcm]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LCM OCA]. <br> | + | <table><tr><td colspan='2'>[[2lcm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LCM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LCM FirstGlance]. <br> |
| - | <b> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lcm OCA], [https://pdbe.org/2lcm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lcm RCSB], [https://www.ebi.ac.uk/pdbsum/2lcm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lcm ProSAT]</span></td></tr> |
| - | + | </table> | |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CAC1B_HUMAN CAC1B_HUMAN] Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Darbon H]] |
| - | [[Category: | + | [[Category: De waar M]] |
| - | [[Category: | + | [[Category: Douzi B]] |
Current revision
NMR structure of S3-4 peptide
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