2kg7
From Proteopedia
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==Structure and features of the complex formed by the tuberculosis virulence factors Rv0287 and Rv0288== | ==Structure and features of the complex formed by the tuberculosis virulence factors Rv0287 and Rv0288== | ||
| - | <StructureSection load='2kg7' size='340' side='right' caption='[[2kg7 | + | <StructureSection load='2kg7' size='340' side='right'caption='[[2kg7]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | [[2kg7]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2kg7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KG7 FirstGlance]. <br> |
| - | <b> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <b>Resources:</b> <span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kg7 OCA], [https://pdbe.org/2kg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kg7 RCSB], [https://www.ebi.ac.uk/pdbsum/2kg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kg7 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ESXG_MYCTU ESXG_MYCTU] EsxG, in complex with EsxH, disrupts ESCRT function and impairs host phagosome maturation, thereby promoting intracellular bacterial growth. The complex acts by interacting, via EsxH, with the host hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/HRS), a component of the ESCRT machinery. EsxG stabilizes EsxH in the host cytosol.<ref>PMID:24204276</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
| - | [[Image:Consurf_key_small.gif|right]] | + | [[Image:Consurf_key_small.gif|200px|right]] |
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/2kg7_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/2kg7_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kg7 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
== References == | == References == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Mycobacterium tuberculosis]] | + | [[Category: Large Structures]] |
| - | [[Category: Carr | + | [[Category: Mycobacterium tuberculosis H37Rv]] |
| - | [[Category: Ilghari | + | [[Category: Carr MD]] |
| - | [[Category: Kirsty | + | [[Category: Ilghari D]] |
| - | [[Category: Philip | + | [[Category: Kirsty LL]] |
| - | [[Category: Veverka | + | [[Category: Philip RS]] |
| - | [[Category: Waters | + | [[Category: Veverka VL]] |
| - | + | [[Category: Waters LC]] | |
| - | + | ||
Current revision
Structure and features of the complex formed by the tuberculosis virulence factors Rv0287 and Rv0288
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