3wp1

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==Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl==
==Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl==
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<StructureSection load='3wp1' size='340' side='right' caption='[[3wp1]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='3wp1' size='340' side='right'caption='[[3wp1]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wp1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WP1 OCA]. <br>
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<table><tr><td colspan='2'>[[3wp1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WP1 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.804&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wp0|3wp0]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wp1 OCA], [https://pdbe.org/3wp1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wp1 RCSB], [https://www.ebi.ac.uk/pdbsum/3wp1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wp1 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dlg4, Dlgh4, Psd95 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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== Function ==
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wp1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wp1 RCSB], [http://www.ebi.ac.uk/pdbsum/3wp1 PDBsum]</span></td></tr>
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[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>
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<table>
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<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl.,Zhu J, Shang Y, Wan Q, Xia Y, Chen J, Du Q, Zhang M Cell Res. 2014 Feb 11. doi: 10.1038/cr.2014.16. PMID:24513855<ref>PMID:24513855</ref>
Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl.,Zhu J, Shang Y, Wan Q, Xia Y, Chen J, Du Q, Zhang M Cell Res. 2014 Feb 11. doi: 10.1038/cr.2014.16. PMID:24513855<ref>PMID:24513855</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3wp1" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Postsynaptic density protein 3D structures|Postsynaptic density protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Homo sapiens]]
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[[Category: Chen, J.]]
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[[Category: Large Structures]]
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[[Category: Du, Q.]]
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[[Category: Rattus norvegicus]]
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[[Category: Shang, Y.]]
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[[Category: Chen J]]
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[[Category: Wan, Q.]]
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[[Category: Du Q]]
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[[Category: Xia, Y.]]
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[[Category: Shang Y]]
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[[Category: Zhang, M.]]
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[[Category: Wan Q]]
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[[Category: Zhu, J.]]
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[[Category: Xia Y]]
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[[Category: Cell polarity]]
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[[Category: Zhang M]]
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[[Category: Maguk]]
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[[Category: Zhu J]]
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[[Category: Peptide binding protein]]
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[[Category: Phosphorylation]]
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[[Category: Phosphorylation dependent]]
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[[Category: Tumor suppressor]]
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Current revision

Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl

PDB ID 3wp1

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