This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4l1d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:08, 20 September 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Voltage-gated sodium channel beta3 subunit Ig domain==
==Voltage-gated sodium channel beta3 subunit Ig domain==
-
<StructureSection load='4l1d' size='340' side='right' caption='[[4l1d]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+
<StructureSection load='4l1d' size='340' side='right'caption='[[4l1d]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4l1d]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1D OCA]. <br>
+
<table><tr><td colspan='2'>[[4l1d]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L1D FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2x1x|2x1x]], [[1i8l|1i8l]], [[1f97|1f97]]</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIAA1158, SCN3B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l1d OCA], [https://pdbe.org/4l1d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l1d RCSB], [https://www.ebi.ac.uk/pdbsum/4l1d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l1d ProSAT]</span></td></tr>
-
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
+
</table>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l1d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l1d RCSB], [http://www.ebi.ac.uk/pdbsum/4l1d PDBsum]</span></td></tr>
+
-
<table>
+
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/SCN3B_HUMAN SCN3B_HUMAN]] Brugada syndrome. The disease is caused by mutations affecting the gene represented in this entry.
+
[https://www.uniprot.org/uniprot/SCN3B_HUMAN SCN3B_HUMAN] Brugada syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/SCN3B_HUMAN SCN3B_HUMAN]] Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity).
+
[https://www.uniprot.org/uniprot/SCN3B_HUMAN SCN3B_HUMAN] Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 17:
Crystal Structure and Molecular Imaging of the Nav Channel beta3 Subunit Indicates a Trimeric Assembly.,Namadurai S, Balasuriya D, Rajappa R, Wiemhofer M, Stott K, Klingauf J, Edwardson JM, Chirgadze DY, Jackson AP J Biol Chem. 2014 Apr 11;289(15):10797-811. doi: 10.1074/jbc.M113.527994. Epub, 2014 Feb 24. PMID:24567321<ref>PMID:24567321</ref>
Crystal Structure and Molecular Imaging of the Nav Channel beta3 Subunit Indicates a Trimeric Assembly.,Namadurai S, Balasuriya D, Rajappa R, Wiemhofer M, Stott K, Klingauf J, Edwardson JM, Chirgadze DY, Jackson AP J Biol Chem. 2014 Apr 11;289(15):10797-811. doi: 10.1074/jbc.M113.527994. Epub, 2014 Feb 24. PMID:24567321<ref>PMID:24567321</ref>
-
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4l1d" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Chirgadze, D Y.]]
+
[[Category: Large Structures]]
-
[[Category: Jackson, A P.]]
+
[[Category: Chirgadze DY]]
-
[[Category: Klingauf, J.]]
+
[[Category: Jackson AP]]
-
[[Category: Namadurai, S.]]
+
[[Category: Klingauf J]]
-
[[Category: Rajappa, R.]]
+
[[Category: Namadurai S]]
-
[[Category: Stott, K.]]
+
[[Category: Rajappa R]]
-
[[Category: Weimhofer, M.]]
+
[[Category: Stott K]]
-
[[Category: Membrane]]
+
[[Category: Weimhofer M]]
-
[[Category: Membrane protein]]
+
-
[[Category: Sodium channel]]
+
-
[[Category: Sodium channel alpha subunit]]
+
-
[[Category: V-type immunoglobulin fold]]
+
-
[[Category: Voltage-gated]]
+

Current revision

Voltage-gated sodium channel beta3 subunit Ig domain

PDB ID 4l1d

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4l1d"
Personal tools