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2kmd

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==Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to co-activator CBP==
==Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to co-activator CBP==
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<StructureSection load='2kmd' size='340' side='right' caption='[[2kmd]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2kmd' size='340' side='right'caption='[[2kmd]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2kmd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMD OCA]. <br>
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<table><tr><td colspan='2'>[[2kmd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KMD FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jv3|2jv3]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jv3|2jv3]]</div></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ets1, Ets-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ets1, Ets-1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kmd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kmd OCA], [https://pdbe.org/2kmd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kmd RCSB], [https://www.ebi.ac.uk/pdbsum/2kmd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kmd ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kmd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kmd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kmd RCSB], [http://www.ebi.ac.uk/pdbsum/2kmd PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[[https://www.uniprot.org/uniprot/ETS1_MOUSE ETS1_MOUSE]] Transcription factor.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/km/2kmd_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/km/2kmd_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kmd ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP.,Nelson ML, Kang HS, Lee GM, Blaszczak AG, Lau DK, McIntosh LP, Graves BJ Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10026-31. Epub 2010 May 13. PMID:20534573<ref>PMID:20534573</ref>
Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP.,Nelson ML, Kang HS, Lee GM, Blaszczak AG, Lau DK, McIntosh LP, Graves BJ Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10026-31. Epub 2010 May 13. PMID:20534573<ref>PMID:20534573</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2kmd" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ets1|Ets1]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Mus musculus]]
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[[Category: Large Structures]]
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[[Category: Blaszczak, A G.]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Graves, B J.]]
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[[Category: Blaszczak, A G]]
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[[Category: Kang, H.]]
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[[Category: Graves, B J]]
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[[Category: Lau, D K.W.]]
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[[Category: Kang, H]]
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[[Category: Lee, G M.]]
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[[Category: Lau, D K.W]]
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[[Category: McIntosh, L P.]]
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[[Category: Lee, G M]]
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[[Category: Nelson, M L.]]
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[[Category: McIntosh, L P]]
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[[Category: Nelson, M L]]
[[Category: Conformational dynamic]]
[[Category: Conformational dynamic]]
[[Category: Ets-1]]
[[Category: Ets-1]]

Current revision

Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to co-activator CBP

PDB ID 2kmd

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