4owf

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==Crystal structure of the NEMO CoZi in complex with HOIP NZF1 domain==
==Crystal structure of the NEMO CoZi in complex with HOIP NZF1 domain==
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<StructureSection load='4owf' size='340' side='right' caption='[[4owf]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4owf' size='340' side='right'caption='[[4owf]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4owf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OWF OCA]. <br>
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<table><tr><td colspan='2'>[[4owf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OWF FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ikbkg,Nemo ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), RNF31,ZIBRA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4owf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4owf OCA], [https://pdbe.org/4owf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4owf RCSB], [https://www.ebi.ac.uk/pdbsum/4owf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4owf ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4owf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4owf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4owf RCSB], [http://www.ebi.ac.uk/pdbsum/4owf PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/NEMO_MOUSE NEMO_MOUSE] Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (By similarity).<ref>PMID:9927690</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Mechanism underlying IKK activation mediated by the linear ubiquitin chain assembly complex (LUBAC).,Fujita H, Rahighi S, Akita M, Kato R, Sasaki Y, Wakatsuki S, Iwai K Mol Cell Biol. 2014 Jan 27. PMID:24469399<ref>PMID:24469399</ref>
Mechanism underlying IKK activation mediated by the linear ubiquitin chain assembly complex (LUBAC).,Fujita H, Rahighi S, Akita M, Kato R, Sasaki Y, Wakatsuki S, Iwai K Mol Cell Biol. 2014 Jan 27. PMID:24469399<ref>PMID:24469399</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4owf" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Fujita, H.]]
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[[Category: Mus musculus]]
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[[Category: Iwai, K.]]
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[[Category: Fujita H]]
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[[Category: Kato, R.]]
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[[Category: Iwai K]]
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[[Category: Kawasaki, M.]]
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[[Category: Kato R]]
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[[Category: Rahighi, S.]]
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[[Category: Kawasaki M]]
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[[Category: Wakatsuki, S.]]
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[[Category: Rahighi S]]
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[[Category: Hoip]]
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[[Category: Wakatsuki S]]
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[[Category: Lubac]]
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[[Category: Nemo]]
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[[Category: Nf-kappa b]]
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Current revision

Crystal structure of the NEMO CoZi in complex with HOIP NZF1 domain

PDB ID 4owf

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