We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2l6a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:39, 15 May 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Three-dimensional structure of the N-terminal effector PYRIN domain of NLRP12==
==Three-dimensional structure of the N-terminal effector PYRIN domain of NLRP12==
-
<StructureSection load='2l6a' size='340' side='right' caption='[[2l6a]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='2l6a' size='340' side='right'caption='[[2l6a]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2l6a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L6A OCA]. <br>
+
<table><tr><td colspan='2'>[[2l6a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L6A FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NLRP12, NALP12, PYPAF7, RNO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l6a OCA], [https://pdbe.org/2l6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l6a RCSB], [https://www.ebi.ac.uk/pdbsum/2l6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l6a ProSAT]</span></td></tr>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l6a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l6a RCSB], [http://www.ebi.ac.uk/pdbsum/2l6a PDBsum]</span></td></tr>
+
</table>
-
<table>
+
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/NAL12_HUMAN NAL12_HUMAN]] NLRP12-associated hereditary periodic fever syndrome. The disease is caused by mutations affecting the gene represented in this entry.
+
[https://www.uniprot.org/uniprot/NAL12_HUMAN NAL12_HUMAN] NLRP12-associated hereditary periodic fever syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/NAL12_HUMAN NAL12_HUMAN]] May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
+
[https://www.uniprot.org/uniprot/NAL12_HUMAN NAL12_HUMAN] May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 17: Line 17:
The NLRP12 Pyrin Domain: Structure, Dynamics, and Functional Insights.,Pinheiro AS, Eibl C, Ekman-Vural Z, Schwarzenbacher R, Peti W J Mol Biol. 2011 Nov 4;413(4):790-803. Epub 2011 Sep 28. PMID:21978668<ref>PMID:21978668</ref>
The NLRP12 Pyrin Domain: Structure, Dynamics, and Functional Insights.,Pinheiro AS, Eibl C, Ekman-Vural Z, Schwarzenbacher R, Peti W J Mol Biol. 2011 Nov 4;413(4):790-803. Epub 2011 Sep 28. PMID:21978668<ref>PMID:21978668</ref>
-
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 2l6a" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Pyrin domain|Pyrin domain]]
== References ==
== References ==
<references/>
<references/>
Line 24: Line 28:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Peti, W.]]
+
[[Category: Large Structures]]
-
[[Category: Pinheiro, A S.]]
+
[[Category: Peti W]]
-
[[Category: Death domain]]
+
[[Category: Pinheiro AS]]
-
[[Category: Nlrp12]]
+
-
[[Category: Pyrin]]
+
-
[[Category: Signaling protein]]
+

Current revision

Three-dimensional structure of the N-terminal effector PYRIN domain of NLRP12

PDB ID 2l6a

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2l6a"
Personal tools