2l76

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==Solution NMR structure of human NFATC2IP ubiquitin-like domain, NFATC2IP_244_338, NESG target HT65A/OCSP target hs00387_244_338/SGC-toronto==
==Solution NMR structure of human NFATC2IP ubiquitin-like domain, NFATC2IP_244_338, NESG target HT65A/OCSP target hs00387_244_338/SGC-toronto==
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<StructureSection load='2l76' size='340' side='right' caption='[[2l76]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2l76' size='340' side='right'caption='[[2l76]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2l76]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L76 OCA]. <br>
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<table><tr><td colspan='2'>[[2l76]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L76 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NFATC2IP, NIP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l76 OCA], [https://pdbe.org/2l76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l76 RCSB], [https://www.ebi.ac.uk/pdbsum/2l76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l76 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l76 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l76 RCSB], [http://www.ebi.ac.uk/pdbsum/2l76 PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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== References ==
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[https://www.uniprot.org/uniprot/NF2IP_HUMAN NF2IP_HUMAN] In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Dhe-Paganon, S.]]
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[[Category: Arrowsmith CH]]
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[[Category: Doherty, R.]]
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[[Category: Dhe-Paganon S]]
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[[Category: Houliston, S.]]
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[[Category: Doherty R]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Houliston S]]
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[[Category: OCSP, Ontario Centre for Structural Proteomics.]]
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[[Category: Semesi A]]
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[[Category: Semesi, A.]]
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[[Category: Wu B]]
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[[Category: Wu, B.]]
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[[Category: Yee A]]
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[[Category: Yee, A.]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Ocsp]]
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[[Category: Ontario centre for structural proteomic]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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[[Category: Transcription]]
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[[Category: Ubiquitin-like domain]]
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Current revision

Solution NMR structure of human NFATC2IP ubiquitin-like domain, NFATC2IP_244_338, NESG target HT65A/OCSP target hs00387_244_338/SGC-toronto

PDB ID 2l76

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