2j0e

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==THREE DIMENSIONAL STRUCTURE AND CATALYTIC MECHANISM OF 6-PHOSPHOGLUCONOLACTONASE FROM TRYPANOSOMA BRUCEI==
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<StructureSection load='2j0e' size='340' side='right' caption='[[2j0e]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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==Three dimensional structure and catalytic mechanism of 6- phosphogluconolactonase from Trypanosoma brucei==
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<StructureSection load='2j0e' size='340' side='right'caption='[[2j0e]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2j0e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J0E OCA]. <br>
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<table><tr><td colspan='2'>[[2j0e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J0E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J0E FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j0e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j0e RCSB], [http://www.ebi.ac.uk/pdbsum/2j0e PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j0e OCA], [https://pdbe.org/2j0e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j0e RCSB], [https://www.ebi.ac.uk/pdbsum/2j0e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j0e ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9GRG6_9TRYP Q9GRG6_9TRYP]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j0/2j0e_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j0/2j0e_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j0e ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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Three dimensional structure and implications for the catalytic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei.,Delarue M, Duclert-Savatier N, Miclet E, Haouz A, Giganti D, Ouazzani J, Lopez P, Nilges M, Stoven V J Mol Biol. 2007 Feb 23;366(3):868-81. Epub 2006 Nov 22. PMID:17196981<ref>PMID:17196981</ref>
Three dimensional structure and implications for the catalytic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei.,Delarue M, Duclert-Savatier N, Miclet E, Haouz A, Giganti D, Ouazzani J, Lopez P, Nilges M, Stoven V J Mol Biol. 2007 Feb 23;366(3):868-81. Epub 2006 Nov 22. PMID:17196981<ref>PMID:17196981</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2j0e" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 6-phosphogluconolactonase]]
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[[Category: Large Structures]]
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[[Category: Trypanosoma brucei]]
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[[Category: Delarue, M.]]
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[[Category: Duclert-Savatier, N.]]
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[[Category: Giganti, D.]]
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[[Category: Haouz, A.]]
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[[Category: Lopez, P.]]
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[[Category: Miclet, E.]]
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[[Category: Nilges, M.]]
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[[Category: Ouazzani, J.]]
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[[Category: Stoven, V.]]
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[[Category: Catalytic mechanism]]
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[[Category: Hydrolase]]
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[[Category: Pentose phosphate pathway]]
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[[Category: Trypanosoma brucei]]
[[Category: Trypanosoma brucei]]
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[[Category: Zinc binding site]]
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[[Category: Delarue M]]
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[[Category: Duclert-Savatier N]]
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[[Category: Giganti D]]
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[[Category: Haouz A]]
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[[Category: Lopez P]]
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[[Category: Miclet E]]
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[[Category: Nilges M]]
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[[Category: Ouazzani J]]
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[[Category: Stoven V]]

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Three dimensional structure and catalytic mechanism of 6- phosphogluconolactonase from Trypanosoma brucei

PDB ID 2j0e

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