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2l03

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==Spatial structure of water-soluble Lynx1.==
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<StructureSection load='2l03' size='340' side='right' caption='[[2l03]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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==Spatial structure of water-soluble Lynx1==
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<StructureSection load='2l03' size='340' side='right'caption='[[2l03]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2l03]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L03 OCA]. <br>
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<table><tr><td colspan='2'>[[2l03]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L03 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LYNX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l03 OCA], [https://pdbe.org/2l03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l03 RCSB], [https://www.ebi.ac.uk/pdbsum/2l03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l03 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l03 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l03 RCSB], [http://www.ebi.ac.uk/pdbsum/2l03 PDBsum]</span></td></tr>
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== Function ==
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<table>
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[https://www.uniprot.org/uniprot/LYNX1_HUMAN LYNX1_HUMAN] Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). In brain, isoform 2 modulates functional properties of nAChRs to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha(4)beta(2) nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha(4)beta(2) nAChRs (By similarity). Prevents plasticity in the primary visual cortex late in life (By similarity). In keratinocytes, isoform 3 delays differentiation and prevents apoptosis.<ref>PMID:16575903</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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NMR structure and action on nicotinic acetylcholine receptors of water-soluble domain of human LYNX1.,Lyukmanova EN, Shenkarev ZO, Shulepko MA, Mineev KS, D'Hoedt D, Kasheverov IE, Filkin SY, Krivolapova AP, Janickova H, Dolezal V, Dolgikh DA, Arseniev AS, Bertrand D, Tsetlin VI, Kirpichnikov MP J Biol Chem. 2011 Mar 25;286(12):10618-27. Epub 2011 Jan 20. PMID:21252236<ref>PMID:21252236</ref>
NMR structure and action on nicotinic acetylcholine receptors of water-soluble domain of human LYNX1.,Lyukmanova EN, Shenkarev ZO, Shulepko MA, Mineev KS, D'Hoedt D, Kasheverov IE, Filkin SY, Krivolapova AP, Janickova H, Dolezal V, Dolgikh DA, Arseniev AS, Bertrand D, Tsetlin VI, Kirpichnikov MP J Biol Chem. 2011 Mar 25;286(12):10618-27. Epub 2011 Jan 20. PMID:21252236<ref>PMID:21252236</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2l03" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arseniev, A S.]]
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[[Category: Large Structures]]
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[[Category: Mineev, K S.]]
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[[Category: Arseniev AS]]
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[[Category: Shenkarev, Z O.]]
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[[Category: Mineev KS]]
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[[Category: Acetylcholine receptor]]
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[[Category: Shenkarev ZO]]
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[[Category: Endogenic neuromodulator]]
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[[Category: Lynx1]]
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[[Category: Signaling protein]]
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[[Category: Three-finger toxin]]
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Current revision

Spatial structure of water-soluble Lynx1

PDB ID 2l03

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