4h5s

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==Complex structure of Necl-2 and CRTAM==
==Complex structure of Necl-2 and CRTAM==
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<StructureSection load='4h5s' size='340' side='right' caption='[[4h5s]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='4h5s' size='340' side='right'caption='[[4h5s]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4h5s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H5S OCA]. <br>
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<table><tr><td colspan='2'>[[4h5s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H5S FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CRTAM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CADM1, IGSF4, IGSF4A, NECL2, SYNCAM, TSLC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h5s OCA], [https://pdbe.org/4h5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h5s RCSB], [https://www.ebi.ac.uk/pdbsum/4h5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h5s ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h5s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h5s RCSB], [http://www.ebi.ac.uk/pdbsum/4h5s PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/CRTAM_HUMAN CRTAM_HUMAN] Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.<ref>PMID:15811952</ref> [UniProtKB:Q149L7]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Competition of Cell Adhesion and Immune Recognition: Insights into the Interaction between CRTAM and Nectin-like 2.,Zhang S, Lu G, Qi J, Li Y, Zhang Z, Zhang B, Fan Z, Yan J, Gao GF Structure. 2013 Jul 16. pii: S0969-2126(13)00207-4. doi:, 10.1016/j.str.2013.06.006. PMID:23871486<ref>PMID:23871486</ref>
Competition of Cell Adhesion and Immune Recognition: Insights into the Interaction between CRTAM and Nectin-like 2.,Zhang S, Lu G, Qi J, Li Y, Zhang Z, Zhang B, Fan Z, Yan J, Gao GF Structure. 2013 Jul 16. pii: S0969-2126(13)00207-4. doi:, 10.1016/j.str.2013.06.006. PMID:23871486<ref>PMID:23871486</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4h5s" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Gao, G F.]]
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[[Category: Large Structures]]
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[[Category: Li, Y.]]
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[[Category: Gao GF]]
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[[Category: Lu, G.]]
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[[Category: Li Y]]
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[[Category: Qi, J.]]
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[[Category: Lu G]]
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[[Category: Yan, J.]]
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[[Category: Qi J]]
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[[Category: Zhang, B.]]
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[[Category: Yan J]]
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[[Category: Zhang, S.]]
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[[Category: Zhang B]]
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[[Category: Zhang, Z.]]
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[[Category: Zhang S]]
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[[Category: Cell adhesion]]
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[[Category: Zhang Z]]
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[[Category: Ig fold]]
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[[Category: Immune recognition]]
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Current revision

Complex structure of Necl-2 and CRTAM

PDB ID 4h5s

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