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4mxa

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==CDPK1 from Neospora caninum in complex with inhibitor RM-1-132==
==CDPK1 from Neospora caninum in complex with inhibitor RM-1-132==
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<StructureSection load='4mxa' size='340' side='right' caption='[[4mxa]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='4mxa' size='340' side='right'caption='[[4mxa]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4mxa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neocl Neocl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MXA OCA]. <br>
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<table><tr><td colspan='2'>[[4mxa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neospora_caninum_Liverpool Neospora caninum Liverpool]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MXA FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BK7:3-(6-ETHOXYNAPHTHALEN-2-YL)-1-(PIPERIDIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE'>BK7</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4m97|4m97]], [[3sx9|3sx9]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BK7:3-(6-ETHOXYNAPHTHALEN-2-YL)-1-(PIPERIDIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE'>BK7</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDPK1, NCLIV_011980, XP_003880764 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=572307 NEOCL])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mxa OCA], [https://pdbe.org/4mxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mxa RCSB], [https://www.ebi.ac.uk/pdbsum/4mxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mxa ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mxa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mxa RCSB], [http://www.ebi.ac.uk/pdbsum/4mxa PDBsum]</span></td></tr>
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== Function ==
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<table>
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[https://www.uniprot.org/uniprot/F0V9W9_NEOCL F0V9W9_NEOCL]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy.,Ojo KK, Reid MC, Kallur Siddaramaiah L, Muller J, Winzer P, Zhang Z, Keyloun KR, Vidadala RS, Merritt EA, Hol WG, Maly DJ, Fan E, Van Voorhis WC, Hemphill A PLoS One. 2014 Mar 28;9(3):e92929. doi: 10.1371/journal.pone.0092929. eCollection, 2014. PMID:24681759<ref>PMID:24681759</ref>
Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy.,Ojo KK, Reid MC, Kallur Siddaramaiah L, Muller J, Winzer P, Zhang Z, Keyloun KR, Vidadala RS, Merritt EA, Hol WG, Maly DJ, Fan E, Van Voorhis WC, Hemphill A PLoS One. 2014 Mar 28;9(3):e92929. doi: 10.1371/journal.pone.0092929. eCollection, 2014. PMID:24681759<ref>PMID:24681759</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4mxa" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Calcium/calmodulin-dependent protein kinase]]
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[[Category: Large Structures]]
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[[Category: Neocl]]
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[[Category: Neospora caninum Liverpool]]
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[[Category: Merritt, E A.]]
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[[Category: Merritt EA]]
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[[Category: Atp-binding]]
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[[Category: Calcium-binding]]
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[[Category: Serine/threonine protein kinase]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

CDPK1 from Neospora caninum in complex with inhibitor RM-1-132

PDB ID 4mxa

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