4ft8
From Proteopedia
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==E. coli Catabolite Activator Protein with Cobalt and Sulfate Ligands== | ==E. coli Catabolite Activator Protein with Cobalt and Sulfate Ligands== | ||
| - | <StructureSection load='4ft8' size='340' side='right' caption='[[4ft8]], [[Resolution|resolution]] 1.97Å' scene=''> | + | <StructureSection load='4ft8' size='340' side='right'caption='[[4ft8]], [[Resolution|resolution]] 1.97Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4ft8]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4ft8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FT8 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.966Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ft8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ft8 OCA], [https://pdbe.org/4ft8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ft8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ft8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ft8 ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [https://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref> | ||
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| + | ==See Also== | ||
| + | *[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Escherichia coli K-12]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Lawson CL]] |
| - | [[Category: | + | [[Category: Rao R]] |
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Current revision
E. coli Catabolite Activator Protein with Cobalt and Sulfate Ligands
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