This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4pfd
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4pfd is ON HOLD Authors: Neres, J., Panda, M. Description: Crystal structure of M. tuberculosis in complex with a cBT -non-covalent adduct) |
|||
| (7 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of M. tuberculosis in complex with a cBT - non-covalent adduct== | |
| - | + | <StructureSection load='4pfd' size='340' side='right'caption='[[4pfd]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4pfd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PFD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2R2:[4-(2-METHOXYETHYL)PIPERAZIN-1-YL][6-METHYL-7-NITRO-5-(TRIFLUOROMETHYL)-1,3-BENZOTHIAZOL-2-YL]METHANONE'>2R2</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pfd OCA], [https://pdbe.org/4pfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pfd RCSB], [https://www.ebi.ac.uk/pdbsum/4pfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pfd ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DPRE1_MYCTU DPRE1_MYCTU] Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (DPR) to yield decaprenylphosphoryl 2-keto-ribose (DPX).<ref>PMID:16291675</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
| + | [[Category: Cole S]] | ||
| + | [[Category: Neres J]] | ||
| + | [[Category: Panda M]] | ||
Current revision
Crystal structure of M. tuberculosis in complex with a cBT - non-covalent adduct
| |||||||||||
