4mid
From Proteopedia
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==Crystal Structure of Activin A/BMP2 chimera== | ==Crystal Structure of Activin A/BMP2 chimera== | ||
| - | <StructureSection load='4mid' size='340' side='right' caption='[[4mid]], [[Resolution|resolution]] 2.14Å' scene=''> | + | <StructureSection load='4mid' size='340' side='right'caption='[[4mid]], [[Resolution|resolution]] 2.14Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4mid]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MID OCA]. <br> | + | <table><tr><td colspan='2'>[[4mid]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MID FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.139Å</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mid OCA], [https://pdbe.org/4mid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mid RCSB], [https://www.ebi.ac.uk/pdbsum/4mid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mid ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/INHBA_HUMAN INHBA_HUMAN] Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.[https://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN] Induces cartilage and bone formation. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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An Activin A/BMP2 Chimera Displays Bone Healing Properties Superior to Those of BMP2.,Yoon BH, Esquivies L, Ahn C, Gray PC, Ye SK, Kwiatkowski W, Choe S J Bone Miner Res. 2014 Apr 1. doi: 10.1002/jbmr.2238. PMID:24692083<ref>PMID:24692083</ref> | An Activin A/BMP2 Chimera Displays Bone Healing Properties Superior to Those of BMP2.,Yoon BH, Esquivies L, Ahn C, Gray PC, Ye SK, Kwiatkowski W, Choe S J Bone Miner Res. 2014 Apr 1. doi: 10.1002/jbmr.2238. PMID:24692083<ref>PMID:24692083</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | <div class="pdbe-citations 4mid" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Bone morphogenetic protein 3D structures|Bone morphogenetic protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Esquivies L]] |
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Current revision
Crystal Structure of Activin A/BMP2 chimera
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