This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4crw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:15, 20 December 2023) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Complex of human DDX6 (RECA-C) and CNOT1 (MIF4G)==
==Complex of human DDX6 (RECA-C) and CNOT1 (MIF4G)==
-
<StructureSection load='4crw' size='340' side='right' caption='[[4crw]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
+
<StructureSection load='4crw' size='340' side='right'caption='[[4crw]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4crw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRW OCA]. <br>
+
<table><tr><td colspan='2'>[[4crw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CRW FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
-
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gml|4gml]], [[4gmj|4gmj]], [[2wax|2wax]], [[2way|2way]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4crw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4crw OCA], [https://pdbe.org/4crw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4crw RCSB], [https://www.ebi.ac.uk/pdbsum/4crw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4crw ProSAT]</span></td></tr>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4crw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4crw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4crw RCSB], [http://www.ebi.ac.uk/pdbsum/4crw PDBsum]</span></td></tr>
+
</table>
-
<table>
+
-
== Disease ==
+
-
[[http://www.uniprot.org/uniprot/DDX6_HUMAN DDX6_HUMAN]] Note=A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as B-cell lymphomas. Translocation t(11;14)(q23;q32).
+
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/CNOT1_HUMAN CNOT1_HUMAN]] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.<ref>PMID:10637334</ref> <ref>PMID:16778766</ref> [[http://www.uniprot.org/uniprot/DDX6_HUMAN DDX6_HUMAN]] In the process of mRNA degradation, may play a role in mRNA decapping.
+
[https://www.uniprot.org/uniprot/CNOT1_HUMAN CNOT1_HUMAN] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.<ref>PMID:10637334</ref> <ref>PMID:16778766</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 16:
A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing.,Chen Y, Boland A, Kuzuoglu-Ozturk D, Bawankar P, Loh B, Chang CT, Weichenrieder O, Izaurralde E Mol Cell. 2014 Apr 22. pii: S1097-2765(14)00267-6. doi:, 10.1016/j.molcel.2014.03.034. PMID:24768540<ref>PMID:24768540</ref>
A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing.,Chen Y, Boland A, Kuzuoglu-Ozturk D, Bawankar P, Loh B, Chang CT, Weichenrieder O, Izaurralde E Mol Cell. 2014 Apr 22. pii: S1097-2765(14)00267-6. doi:, 10.1016/j.molcel.2014.03.034. PMID:24768540<ref>PMID:24768540</ref>
-
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4crw" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Boland, A.]]
+
[[Category: Homo sapiens]]
-
[[Category: Chen, Y.]]
+
[[Category: Large Structures]]
-
[[Category: Izaurralde, E.]]
+
[[Category: Boland A]]
-
[[Category: Weichenrieder, O.]]
+
[[Category: Chen Y]]
-
[[Category: Ccr4-not]]
+
[[Category: Izaurralde E]]
-
[[Category: Dead-box protein]]
+
[[Category: Weichenrieder O]]
-
[[Category: Eif4a]]
+
-
[[Category: Gene regulation]]
+
-
[[Category: Helicase]]
+
-
[[Category: Mirna]]
+
-
[[Category: Mrna deadenylation]]
+
-
[[Category: Mrna decapping]]
+
-
[[Category: Mrna silencing]]
+
-
[[Category: P-body]]
+
-
[[Category: P54]]
+
-
[[Category: Rck]]
+
-
[[Category: Translation]]
+
-
[[Category: Translational repression]]
+

Current revision

Complex of human DDX6 (RECA-C) and CNOT1 (MIF4G)

PDB ID 4crw

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4crw"
Personal tools