2w9l

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==CANINE ADENOVIRUS TYPE 2 FIBRE HEAD IN COMPLEX WITH CAR DOMAIN D1 AND SIALIC ACID==
==CANINE ADENOVIRUS TYPE 2 FIBRE HEAD IN COMPLEX WITH CAR DOMAIN D1 AND SIALIC ACID==
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<StructureSection load='2w9l' size='340' side='right' caption='[[2w9l]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
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<StructureSection load='2w9l' size='340' side='right'caption='[[2w9l]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2w9l]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Canine_adenovirus_2 Canine adenovirus 2] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W9L OCA]. <br>
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<table><tr><td colspan='2'>[[2w9l]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Canine_adenovirus_2 Canine adenovirus 2] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W9L FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GL0:BETA-D-GULOPYRANOSE'>GL0</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.91&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GL0:BETA-D-GULOPYRANOSE'>GL0</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2j12|2j12]], [[1eaj|1eaj]], [[1p69|1p69]], [[1jew|1jew]], [[1kac|1kac]], [[2j2j|2j2j]], [[1p6a|1p6a]], [[1rsf|1rsf]], [[1f5w|1f5w]], [[2j1k|2j1k]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w9l OCA], [https://pdbe.org/2w9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w9l RCSB], [https://www.ebi.ac.uk/pdbsum/2w9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w9l ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w9l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w9l RCSB], [http://www.ebi.ac.uk/pdbsum/2w9l PDBsum]</span></td></tr>
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== Function ==
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<table>
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[https://www.uniprot.org/uniprot/CXAR_HUMAN CXAR_HUMAN] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.<ref>PMID:9096397</ref> <ref>PMID:11734628</ref> <ref>PMID:12297051</ref> <ref>PMID:15800062</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w9/2w9l_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w9/2w9l_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w9l ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution.,Seiradake E, Henaff D, Wodrich H, Billet O, Perreau M, Hippert C, Mennechet F, Schoehn G, Lortat-Jacob H, Dreja H, Ibanes S, Kalatzis V, Wang JP, Finberg RW, Cusack S, Kremer EJ PLoS Pathog. 2009 Jan;5(1):e1000277. Epub 2009 Jan 2. PMID:19119424<ref>PMID:19119424</ref>
The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution.,Seiradake E, Henaff D, Wodrich H, Billet O, Perreau M, Hippert C, Mennechet F, Schoehn G, Lortat-Jacob H, Dreja H, Ibanes S, Kalatzis V, Wang JP, Finberg RW, Cusack S, Kremer EJ PLoS Pathog. 2009 Jan;5(1):e1000277. Epub 2009 Jan 2. PMID:19119424<ref>PMID:19119424</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2w9l" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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[[Category: Canine adenovirus 2]]
[[Category: Canine adenovirus 2]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Billet, O.]]
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[[Category: Large Structures]]
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[[Category: Cusack, S.]]
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[[Category: Billet O]]
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[[Category: Dreja, H.]]
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[[Category: Cusack S]]
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[[Category: Finberg, R W.]]
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[[Category: Dreja H]]
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[[Category: Henaff, D.]]
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[[Category: Finberg RW]]
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[[Category: Hippert, C.]]
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[[Category: Henaff D]]
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[[Category: Ibanes, S.]]
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[[Category: Hippert C]]
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[[Category: Kalatzis, V.]]
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[[Category: Ibanes S]]
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[[Category: Kremer, E J.]]
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[[Category: Kalatzis V]]
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[[Category: Lortat-Jacob, H.]]
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[[Category: Kremer EJ]]
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[[Category: Mennechet, F.]]
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[[Category: Lortat-Jacob H]]
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[[Category: Perreau, M.]]
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[[Category: Mennechet F]]
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[[Category: Schoehn, G.]]
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[[Category: Perreau M]]
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[[Category: Seiradake, E.]]
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[[Category: Schoehn G]]
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[[Category: Wang, J P.]]
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[[Category: Seiradake E]]
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[[Category: Wodrich, H.]]
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[[Category: Wang JP]]
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[[Category: Adenovirus]]
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[[Category: Wodrich H]]
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[[Category: Canine]]
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[[Category: Car]]
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[[Category: Cav-2]]
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[[Category: Cell adhesion]]
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[[Category: Cell junction]]
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[[Category: Cell membrane]]
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[[Category: Complex]]
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[[Category: Coxsackievirus]]
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[[Category: Domain d1]]
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[[Category: Erythrocyte]]
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[[Category: Fiber]]
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[[Category: Fiber head]]
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[[Category: Fiber protein]]
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[[Category: Fibre]]
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[[Category: Fibre head]]
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[[Category: Glycoprotein]]
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[[Category: Hemagglutination]]
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[[Category: Host-virus interaction]]
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[[Category: Immunoglobulin domain]]
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[[Category: Knob]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Palmitate]]
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[[Category: Phosphoprotein]]
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[[Category: Phosphorylation]]
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[[Category: Receptor]]
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[[Category: Red blood cell]]
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[[Category: Secreted]]
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[[Category: Sialic acid]]
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[[Category: Sialyl-lactose]]
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[[Category: Tight junction]]
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[[Category: Transmembrane]]
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[[Category: Virus-receptor complex]]
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Current revision

CANINE ADENOVIRUS TYPE 2 FIBRE HEAD IN COMPLEX WITH CAR DOMAIN D1 AND SIALIC ACID

PDB ID 2w9l

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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