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2o6i

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==Structure of an Enterococcus Faecalis HD Domain Phosphohydrolase==
==Structure of an Enterococcus Faecalis HD Domain Phosphohydrolase==
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<StructureSection load='2o6i' size='340' side='right' caption='[[2o6i]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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<StructureSection load='2o6i' size='340' side='right'caption='[[2o6i]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2o6i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Entfa Entfa]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2hon 2hon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O6I OCA]. <br>
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<table><tr><td colspan='2'>[[2o6i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2hon 2hon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O6I FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EF-1143 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226185 ENTFA])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o6i OCA], [https://pdbe.org/2o6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o6i RCSB], [https://www.ebi.ac.uk/pdbsum/2o6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o6i ProSAT], [https://www.topsan.org/Proteins/MCSG/2o6i TOPSAN]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o6i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o6i RCSB], [http://www.ebi.ac.uk/pdbsum/2o6i PDBsum], [http://www.topsan.org/Proteins/MCSG/2o6i TOPSAN]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q836G9_ENTFA Q836G9_ENTFA]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o6/2o6i_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o6/2o6i_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o6i ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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Characterization of the deoxynucleotide triphosphate triphosphohydrolase (dNTPase) activity of the EF1143 protein from Enterococcus faecalis and crystal structure of the activator-substrate complex.,Vorontsov II, Minasov G, Kiryukhina O, Brunzelle JS, Shuvalova L, Anderson WF J Biol Chem. 2011 Sep 23;286(38):33158-66. Epub 2011 Jul 13. PMID:21757692<ref>PMID:21757692</ref>
Characterization of the deoxynucleotide triphosphate triphosphohydrolase (dNTPase) activity of the EF1143 protein from Enterococcus faecalis and crystal structure of the activator-substrate complex.,Vorontsov II, Minasov G, Kiryukhina O, Brunzelle JS, Shuvalova L, Anderson WF J Biol Chem. 2011 Sep 23;286(38):33158-66. Epub 2011 Jul 13. PMID:21757692<ref>PMID:21757692</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2o6i" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Entfa]]
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[[Category: Enterococcus faecalis V583]]
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[[Category: Anderson, W F.]]
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[[Category: Large Structures]]
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[[Category: Brunzelle, J S.]]
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[[Category: Anderson WF]]
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[[Category: Collart, F R.]]
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[[Category: Brunzelle JS]]
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[[Category: Joachimiak, A.]]
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[[Category: Collart FR]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Joachimiak A]]
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[[Category: Minasov, G.]]
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[[Category: Minasov G]]
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[[Category: Moy, S.]]
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[[Category: Moy S]]
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[[Category: Shuvalova, L.]]
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[[Category: Shuvalova L]]
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[[Category: Vorontsov, I I.]]
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[[Category: Vorontsov II]]
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[[Category: Hd domain]]
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[[Category: Hydrolase]]
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[[Category: Mcsg]]
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[[Category: Midwest center for structural genomic]]
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[[Category: Phosphohydrolase]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Structural genomic]]
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Current revision

Structure of an Enterococcus Faecalis HD Domain Phosphohydrolase

PDB ID 2o6i

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