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2wbv

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==Canine adenovirus 2 fibre head in complex with sialic acid==
==Canine adenovirus 2 fibre head in complex with sialic acid==
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<StructureSection load='2wbv' size='340' side='right' caption='[[2wbv]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='2wbv' size='340' side='right'caption='[[2wbv]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wbv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Canine_adenovirus_2 Canine adenovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBV OCA]. <br>
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<table><tr><td colspan='2'>[[2wbv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Canine_adenovirus_2 Canine adenovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WBV FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2w9l|2w9l]], [[2j2j|2j2j]], [[2j1k|2j1k]], [[2w9w|2w9w]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbv OCA], [https://pdbe.org/2wbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wbv RCSB], [https://www.ebi.ac.uk/pdbsum/2wbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wbv ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wbv RCSB], [http://www.ebi.ac.uk/pdbsum/2wbv PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPIKE_ADECT SPIKE_ADECT] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/2wbv_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/2wbv_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wbv ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution.,Seiradake E, Henaff D, Wodrich H, Billet O, Perreau M, Hippert C, Mennechet F, Schoehn G, Lortat-Jacob H, Dreja H, Ibanes S, Kalatzis V, Wang JP, Finberg RW, Cusack S, Kremer EJ PLoS Pathog. 2009 Jan;5(1):e1000277. Epub 2009 Jan 2. PMID:19119424<ref>PMID:19119424</ref>
The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution.,Seiradake E, Henaff D, Wodrich H, Billet O, Perreau M, Hippert C, Mennechet F, Schoehn G, Lortat-Jacob H, Dreja H, Ibanes S, Kalatzis V, Wang JP, Finberg RW, Cusack S, Kremer EJ PLoS Pathog. 2009 Jan;5(1):e1000277. Epub 2009 Jan 2. PMID:19119424<ref>PMID:19119424</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2wbv" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Canine adenovirus 2]]
[[Category: Canine adenovirus 2]]
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[[Category: Billet, O.]]
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[[Category: Large Structures]]
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[[Category: Cusack, S.]]
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[[Category: Billet O]]
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[[Category: Dreja, H.]]
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[[Category: Cusack S]]
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[[Category: Finberg, R W.]]
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[[Category: Dreja H]]
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[[Category: Henaff, D.]]
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[[Category: Finberg RW]]
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[[Category: Hippert, C.]]
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[[Category: Henaff D]]
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[[Category: Ibanes, S.]]
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[[Category: Hippert C]]
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[[Category: Kalatzis, V.]]
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[[Category: Ibanes S]]
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[[Category: Kremer, E J.]]
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[[Category: Kalatzis V]]
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[[Category: Lortat-Jacob, H.]]
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[[Category: Kremer EJ]]
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[[Category: Mennechet, F.]]
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[[Category: Lortat-Jacob H]]
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[[Category: Perreau, M.]]
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[[Category: Mennechet F]]
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[[Category: Schoehn, G.]]
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[[Category: Perreau M]]
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[[Category: Seiradake, E.]]
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[[Category: Schoehn G]]
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[[Category: Wang, J P.]]
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[[Category: Seiradake E]]
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[[Category: Wodrich, H.]]
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[[Category: Wang JP]]
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[[Category: Adenovirus]]
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[[Category: Wodrich H]]
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[[Category: Cell attachment]]
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[[Category: Erythrocyte]]
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[[Category: Fiber]]
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[[Category: Fiber protein]]
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[[Category: Fibre]]
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[[Category: Head]]
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[[Category: Hemagglutination]]
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[[Category: Knob]]
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[[Category: Red blood cell]]
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[[Category: Sialic acid]]
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[[Category: Sialyl-lactose]]
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[[Category: Structural protein]]
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[[Category: Virus]]
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Current revision

Canine adenovirus 2 fibre head in complex with sialic acid

PDB ID 2wbv

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