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4bwq

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==Crystal structure of U5-15kD in a complex with PQBP1==
==Crystal structure of U5-15kD in a complex with PQBP1==
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<StructureSection load='4bwq' size='340' side='right' caption='[[4bwq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4bwq' size='340' side='right'caption='[[4bwq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bwq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWQ OCA]. <br>
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<table><tr><td colspan='2'>[[4bwq]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BWQ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bws|4bws]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bwq OCA], [https://pdbe.org/4bwq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bwq RCSB], [https://www.ebi.ac.uk/pdbsum/4bwq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bwq ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bwq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bwq RCSB], [http://www.ebi.ac.uk/pdbsum/4bwq PDBsum]</span></td></tr>
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</table>
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<table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/PQBP1_HUMAN PQBP1_HUMAN]] X-linked intellectual deficit, Sutherland-Haan type;X-linked intellectual deficit, Golabi-Ito-Hall type;X-linked intellectual deficit, Porteous type;Hamel cerebro-palato-cardiac syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TXN4A_HUMAN TXN4A_HUMAN]] Essential role in pre-mRNA splicing. [[http://www.uniprot.org/uniprot/PQBP1_HUMAN PQBP1_HUMAN]] May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit.<ref>PMID:10332029</ref> <ref>PMID:10198427</ref> <ref>PMID:12062018</ref>
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[https://www.uniprot.org/uniprot/TXN4A_HUMAN TXN4A_HUMAN] Essential role in pre-mRNA splicing.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein U5-15kD.,Mizuguchi M, Obita T, Serita T, Kojima R, Nabeshima Y, Okazawa H Nat Commun. 2014 Apr 30;5:3822. doi: 10.1038/ncomms4822. PMID:24781215<ref>PMID:24781215</ref>
Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein U5-15kD.,Mizuguchi M, Obita T, Serita T, Kojima R, Nabeshima Y, Okazawa H Nat Commun. 2014 Apr 30;5:3822. doi: 10.1038/ncomms4822. PMID:24781215<ref>PMID:24781215</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4bwq" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[U5-15kD|U5-15kD]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Kojima, R.]]
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[[Category: Large Structures]]
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[[Category: Mizuguchi, M.]]
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[[Category: Kojima R]]
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[[Category: Morimoto, T.]]
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[[Category: Mizuguchi M]]
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[[Category: Nabeshima, Y.]]
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[[Category: Morimoto T]]
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[[Category: Obita, T.]]
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[[Category: Nabeshima Y]]
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[[Category: Okazawa, H.]]
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[[Category: Obita T]]
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[[Category: Serita, T.]]
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[[Category: Okazawa H]]
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[[Category: Neurodegenerative disorder]]
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[[Category: Serita T]]
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[[Category: Transcription]]
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Current revision

Crystal structure of U5-15kD in a complex with PQBP1

PDB ID 4bwq

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