4bpm

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==Crystal structure of a human integral membrane enzyme==
==Crystal structure of a human integral membrane enzyme==
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<StructureSection load='4bpm' size='340' side='right' caption='[[4bpm]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
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<StructureSection load='4bpm' size='340' side='right'caption='[[4bpm]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bpm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPM OCA]. <br>
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<table><tr><td colspan='2'>[[4bpm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BPM FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=LVJ:2-[[2,6-BIS(CHLORANYL)-3-[(2,2-DIMETHYLPROPANOYLAMINO)METHYL]PHENYL]AMINO]-1-METHYL-6-(2-METHYL-2-OXIDANYL-PROPOXY)-N-[2,2,2-TRIS(FLUORANYL)ETHYL]BENZIMIDAZOLE-5-CARBOXAMIDE'>LVJ</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bpd|4bpd]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=LVJ:2-[[2,6-BIS(CHLORANYL)-3-[(2,2-DIMETHYLPROPANOYLAMINO)METHYL]PHENYL]AMINO]-1-METHYL-6-(2-METHYL-2-OXIDANYL-PROPOXY)-N-[2,2,2-TRIS(FLUORANYL)ETHYL]BENZIMIDAZOLE-5-CARBOXAMIDE'>LVJ</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpm OCA], [https://pdbe.org/4bpm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bpm RCSB], [https://www.ebi.ac.uk/pdbsum/4bpm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bpm ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bpm RCSB], [http://www.ebi.ac.uk/pdbsum/4bpm PDBsum]</span></td></tr>
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</table>
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<table>
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== Disease ==
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[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[https://omim.org/entry/246530 246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
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== Function ==
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[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.[https://www.uniprot.org/uniprot/PTGES_HUMAN PTGES_HUMAN] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).<ref>PMID:18682561</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy.,Li D, Howe N, Dukkipati A, Shah ST, Bax BD, Edge C, Bridges A, Hardwicke P, Singh OM, Giblin G, Pautsch A, Pfau R, Schnapp G, Wang M, Olieric V, Caffrey M Cryst Growth Des. 2014 Apr 2;14(4):2034-2047. Epub 2014 Mar 7. PMID:24803849<ref>PMID:24803849</ref>
Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy.,Li D, Howe N, Dukkipati A, Shah ST, Bax BD, Edge C, Bridges A, Hardwicke P, Singh OM, Giblin G, Pautsch A, Pfau R, Schnapp G, Wang M, Olieric V, Caffrey M Cryst Growth Des. 2014 Apr 2;14(4):2034-2047. Epub 2014 Mar 7. PMID:24803849<ref>PMID:24803849</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4bpm" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Prostaglandin E synthase|Prostaglandin E synthase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Prostaglandin-E synthase]]
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[[Category: Large Structures]]
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[[Category: Caffrey, M.]]
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[[Category: Synthetic construct]]
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[[Category: Li, D.]]
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[[Category: Caffrey M]]
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[[Category: Olieric, V.]]
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[[Category: Li D]]
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[[Category: Wang, M.]]
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[[Category: Olieric V]]
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[[Category: Anomalous dispersion]]
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[[Category: Wang M]]
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[[Category: Cancer]]
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[[Category: Drug target]]
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[[Category: In meso crystallization]]
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[[Category: Inflammation]]
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[[Category: Inhibitor]]
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[[Category: Isomerase]]
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[[Category: Leukotriene c4 synthase]]
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[[Category: Lipid metabolism]]
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[[Category: Mapag]]
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[[Category: Membrane protein]]
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[[Category: Membrane-associated proteins in eicosanoid and glutathione metabolism]]
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[[Category: Microcrystal]]
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[[Category: Mpges1]]
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[[Category: Pain]]
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[[Category: S-sad]]
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[[Category: Sulfur-sad]]
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Current revision

Crystal structure of a human integral membrane enzyme

PDB ID 4bpm

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