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4qbw
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4qbw is ON HOLD Authors: xiao.P, wang.X, wang.H.M, fu.X.L, cui.F.A, yu.X, bi.W.X, sun.J.P Description: The second sphere residue T263 is important ...) |
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop== |
| + | <StructureSection load='4qbw' size='340' side='right'caption='[[4qbw]], [[Resolution|resolution]] 1.91Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4qbw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QBW FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.912Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qbw OCA], [https://pdbe.org/4qbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qbw RCSB], [https://www.ebi.ac.uk/pdbsum/4qbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qbw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bi WX]] | ||
| + | [[Category: Cui FA]] | ||
| + | [[Category: Fu XL]] | ||
| + | [[Category: Sun JP]] | ||
| + | [[Category: Wang HM]] | ||
| + | [[Category: Wang X]] | ||
| + | [[Category: Xiao P]] | ||
| + | [[Category: Yu X]] | ||
Current revision
The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop
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Categories: Homo sapiens | Large Structures | Bi WX | Cui FA | Fu XL | Sun JP | Wang HM | Wang X | Xiao P | Yu X
