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2mhs

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==NMR Structure of human Mcl-1==
==NMR Structure of human Mcl-1==
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<StructureSection load='2mhs' size='340' side='right' caption='[[2mhs]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2mhs' size='340' side='right'caption='[[2mhs]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2mhs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHS OCA]. <br>
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<table><tr><td colspan='2'>[[2mhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MHS FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mhs RCSB], [http://www.ebi.ac.uk/pdbsum/2mhs PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhs OCA], [https://pdbe.org/2mhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mhs RCSB], [https://www.ebi.ac.uk/pdbsum/2mhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mhs ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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High-quality NMR structure of human anti-apoptotic protein domain mcl-1(171-327) for cancer drug design.,Liu G, Poppe L, Aoki K, Yamane H, Lewis J, Szyperski T PLoS One. 2014 May 2;9(5):e96521. doi: 10.1371/journal.pone.0096521. eCollection , 2014. PMID:24789074<ref>PMID:24789074</ref>
High-quality NMR structure of human anti-apoptotic protein domain mcl-1(171-327) for cancer drug design.,Liu G, Poppe L, Aoki K, Yamane H, Lewis J, Szyperski T PLoS One. 2014 May 2;9(5):e96521. doi: 10.1371/journal.pone.0096521. eCollection , 2014. PMID:24789074<ref>PMID:24789074</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2mhs" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aoki, K.]]
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[[Category: Homo sapiens]]
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[[Category: Lewis, J.]]
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[[Category: Large Structures]]
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[[Category: Liu, G.]]
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[[Category: Aoki K]]
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[[Category: Poppe, L.]]
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[[Category: Lewis J]]
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[[Category: Szyperski, T.]]
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[[Category: Liu G]]
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[[Category: Yamane, H.]]
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[[Category: Poppe L]]
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[[Category: Apoptosis]]
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[[Category: Szyperski T]]
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[[Category: Bcl-2 family]]
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[[Category: Yamane H]]
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[[Category: Bh domain]]
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[[Category: Cancer drug]]
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[[Category: Gft nmr]]
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[[Category: Mcl-1]]
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Current revision

NMR Structure of human Mcl-1

PDB ID 2mhs

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