This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


112d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:24, 7 February 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:112d.gif|left|200px]]
 
-
{{Structure
+
==MOLECULAR STRUCTURE OF THE G.A BASE PAIR IN DNA AND ITS IMPLICATIONS FOR THE MECHANISM OF TRANSVERSION MUTATIONS==
-
|PDB= 112d |SIZE=350|CAPTION= <scene name='initialview01'>112d</scene>, resolution 2.500&Aring;
+
<StructureSection load='112d' size='340' side='right'caption='[[112d]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[112d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=112D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=112D FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=112d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=112d OCA], [https://pdbe.org/112d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=112d RCSB], [https://www.ebi.ac.uk/pdbsum/112d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=112d ProSAT]</span></td></tr>
-
}}
+
</table>
-
 
+
__TOC__
-
'''MOLECULAR STRUCTURE OF THE G.A BASE PAIR IN DNA AND ITS IMPLICATIONS FOR THE MECHANISM OF TRANSVERSION MUTATIONS'''
+
</StructureSection>
-
 
+
[[Category: Large Structures]]
-
 
+
[[Category: Brown T]]
-
==Overview==
+
[[Category: Hunter WN]]
-
The synthetic deoxydodecamer d(C-G-C-G-A-A-T-T-A-G-C-G) was analyzed by x-ray diffraction methods, and the structure was refined to a residual error of R = 0.17 at 2.5-A resolution (2 sigma data) with 83 water molecules located. The sequence crystallizes as a full turn of a B-DNA helix and contains 2 purine X purine (G.A) base pairs and 10 Watson-Crick base pairs. The analysis shows conclusively that adenine is in the syn orientation with respect to the sugar moiety whereas guanine adopts the usual trans orientation. Nitrogen atoms of both bases are involved in hydrogen bonding with the N-1 of guanine 2.84 A from the N-7 of adenine and the N-6 of adenine within 2.74 A of the O-6 of guanine. The C-1'...C-1' separation is 10.7 A close to that for standard Watson-Crick base pairs. The incorporation of the purine.purine base pairs at two steps in the dodecamer causes little perturbation of either the local or the global conformation of the double helix. Comparison of the structural features with those of the G.T wobble pair and the standard G.C pair suggests a rationale for the differential enzymatic repair of the two types of base-pair mismatches.
+
[[Category: Kennard O]]
-
 
+
[[Category: Kneale G]]
-
==About this Structure==
+
-
112D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=112D OCA].
+
-
 
+
-
==Reference==
+
-
Molecular structure of the G.A base pair in DNA and its implications for the mechanism of transversion mutations., Brown T, Hunter WN, Kneale G, Kennard O, Proc Natl Acad Sci U S A. 1986 Apr;83(8):2402-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3458205 3458205]
+
-
[[Category: Protein complex]]
+
-
[[Category: Brown, T.]]
+
-
[[Category: Hunter, W N.]]
+
-
[[Category: Kennard, O.]]
+
-
[[Category: Kneale, G.]]
+
-
[[Category: b-dna]]
+
-
[[Category: double helix]]
+
-
[[Category: mismatched]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:48:38 2008''
+

Current revision

MOLECULAR STRUCTURE OF THE G.A BASE PAIR IN DNA AND ITS IMPLICATIONS FOR THE MECHANISM OF TRANSVERSION MUTATIONS

PDB ID 112d

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/112d"
Personal tools