4l8w

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==Crystal structure of gamma glutamyl hydrolase (H218N) from zebrafish complex with MTX polyglutamate==
==Crystal structure of gamma glutamyl hydrolase (H218N) from zebrafish complex with MTX polyglutamate==
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<StructureSection load='4l8w' size='340' side='right' caption='[[4l8w]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
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<StructureSection load='4l8w' size='340' side='right'caption='[[4l8w]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4l8w]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8W OCA]. <br>
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<table><tr><td colspan='2'>[[4l8w]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L8W FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l7q|4l7q]], [[4l8f|4l8f]], [[4l8y|4l8y]], [[4l95|4l95]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8w OCA], [https://pdbe.org/4l8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l8w RCSB], [https://www.ebi.ac.uk/pdbsum/4l8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l8w ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l8w RCSB], [http://www.ebi.ac.uk/pdbsum/4l8w PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q6NY42_DANRE Q6NY42_DANRE]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish gamma-glutamyl hydrolase.,Chuankhayan P, Kao TT, Lin CC, Guan HH, Nakagawa A, Fu TF, Chen CJ J Med Chem. 2013 Oct 10;56(19):7625-35. doi: 10.1021/jm401013e. Epub 2013 Sep 27. PMID:24028568<ref>PMID:24028568</ref>
Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish gamma-glutamyl hydrolase.,Chuankhayan P, Kao TT, Lin CC, Guan HH, Nakagawa A, Fu TF, Chen CJ J Med Chem. 2013 Oct 10;56(19):7625-35. doi: 10.1021/jm401013e. Epub 2013 Sep 27. PMID:24028568<ref>PMID:24028568</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4l8w" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Gamma-glutamyl hydrolase]]
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[[Category: Danio rerio]]
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[[Category: Chen, C J.]]
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[[Category: Large Structures]]
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[[Category: Chuankhayan, P.]]
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[[Category: Chen C-J]]
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[[Category: Fu, T F.]]
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[[Category: Chuankhayan P]]
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[[Category: Kao, T T.]]
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[[Category: Fu T-F]]
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[[Category: Hydrolase]]
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[[Category: Kao T-T]]
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[[Category: Sandwiched-like domain]]
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Current revision

Crystal structure of gamma glutamyl hydrolase (H218N) from zebrafish complex with MTX polyglutamate

PDB ID 4l8w

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