4cgw

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==Second TPR of Spaghetti (RPAP3) bound to HSP90 peptide SRMEEVD==
==Second TPR of Spaghetti (RPAP3) bound to HSP90 peptide SRMEEVD==
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<StructureSection load='4cgw' size='340' side='right' caption='[[4cgw]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='4cgw' size='340' side='right'caption='[[4cgw]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cgw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CGW OCA]. <br>
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<table><tr><td colspan='2'>[[4cgw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CGW FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cgq|4cgq]], [[4cgu|4cgu]], [[4cgv|4cgv]], [[4chh|4chh]], [[4ckt|4ckt]], [[4cse|4cse]], [[4cv4|4cv4]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.001&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cgw OCA], [https://pdbe.org/4cgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cgw RCSB], [https://www.ebi.ac.uk/pdbsum/4cgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cgw ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cgw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cgw RCSB], [http://www.ebi.ac.uk/pdbsum/4cgw PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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<div style="background-color:#fffaf0;">
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[https://www.uniprot.org/uniprot/RPAP3_HUMAN RPAP3_HUMAN] Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.<ref>PMID:17643375</ref>
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== Publication Abstract from PubMed ==
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Client protein recruitment to the Hsp90 system depends on cochaperones that bind the client and Hsp90 simultaneously and facilitate their interaction. Hsp90 involvement in the assembly of snoRNPs, RNA polymerases, PI3-kinase-like kinases, and chromatin remodeling complexes depends on the TTT (Tel2-Tti1-Tti2), and R2TP complexes-consisting of the AAA-ATPases Rvb1 and Rvb2, Tah1 (Spagh/RPAP3 in metazoa), and Pih1 (Pih1D1 in humans)-that together provide the connection to Hsp90. The biochemistry underlying R2TP function is still poorly understood. Pih1 in particular, at the heart of the complex, has not been described at a structural level, nor have the multiple protein-protein interactions it mediates been characterized. Here we present a structural and biochemical analysis of Hsp90-Tah1-Pih1, Hsp90-Spagh, and Pih1D1-Tel2 complexes that reveal a domain in Pih1D1 specific for binding CK2 phosphorylation sites, and together define the structural basis by which the R2TP complex connects the Hsp90 chaperone system to the TTT complex.
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Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1.,Pal M, Morgan M, Phelps SE, Roe SM, Parry-Morris S, Downs JA, Polier S, Pearl LH, Prodromou C Structure. 2014 Apr 30. pii: S0969-2126(14)00105-1. doi:, 10.1016/j.str.2014.04.001. PMID:24794838<ref>PMID:24794838</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pal, M.]]
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[[Category: Homo sapiens]]
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[[Category: Roe, S M.]]
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[[Category: Large Structures]]
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[[Category: Chaperone]]
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[[Category: Pal M]]
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[[Category: Pih1]]
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[[Category: Roe SM]]
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[[Category: R2tp]]
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[[Category: Tah1]]
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Current revision

Second TPR of Spaghetti (RPAP3) bound to HSP90 peptide SRMEEVD

PDB ID 4cgw

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