2yin

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==STRUCTURE OF THE COMPLEX BETWEEN DOCK2 AND RAC1.==
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<StructureSection load='2yin' size='340' side='right' caption='[[2yin]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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==STRUCTURE OF THE COMPLEX BETWEEN Dock2 AND Rac1.==
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<StructureSection load='2yin' size='340' side='right'caption='[[2yin]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2yin]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIN OCA]. <br>
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<table><tr><td colspan='2'>[[2yin]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YIN FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vrw|2vrw]], [[1e96|1e96]], [[1i4d|1i4d]], [[1foe|1foe]], [[1mh1|1mh1]], [[1i4l|1i4l]], [[1he1|1he1]], [[1ryf|1ryf]], [[2wkq|2wkq]], [[1ryh|1ryh]], [[1hh4|1hh4]], [[2wkr|2wkr]], [[2wkp|2wkp]], [[2fju|2fju]], [[1g4u|1g4u]], [[1i4t|1i4t]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yin OCA], [https://pdbe.org/2yin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yin RCSB], [https://www.ebi.ac.uk/pdbsum/2yin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yin ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yin OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yin RCSB], [http://www.ebi.ac.uk/pdbsum/2yin PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/DOCK2_HUMAN DOCK2_HUMAN] Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.<ref>PMID:21613211</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (DOCK) Nucleotide Exchange Factors.,Kulkarni K, Yang J, Zhang Z, Barford D J Biol Chem. 2011 Jul 15;286(28):25341-51. Epub 2011 May 24. PMID:21613211<ref>PMID:21613211</ref>
Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (DOCK) Nucleotide Exchange Factors.,Kulkarni K, Yang J, Zhang Z, Barford D J Biol Chem. 2011 Jul 15;286(28):25341-51. Epub 2011 May 24. PMID:21613211<ref>PMID:21613211</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2yin" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dedicator of cytokinesis protein 3D structures|Dedicator of cytokinesis protein 3D structures]]
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*[[Rac 3D structures|Rac 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Barford, D.]]
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[[Category: Large Structures]]
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[[Category: Kulkarni, K A.]]
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[[Category: Barford D]]
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[[Category: Yang, J.]]
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[[Category: Kulkarni KA]]
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[[Category: Zhang, Z.]]
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[[Category: Yang J]]
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[[Category: Apoptosis]]
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[[Category: Zhang Z]]
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[[Category: Dock]]
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[[Category: Dock guanine nucleotide exchange factor]]
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[[Category: Rho gtpase]]
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Current revision

STRUCTURE OF THE COMPLEX BETWEEN Dock2 AND Rac1.

PDB ID 2yin

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